{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:13:20Z","timestamp":1791472400853,"version":"4.3.4"},"reference-count":38,"publisher":"National Academy of Sciences","issue":"30","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,7,29]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Mechanisms controlling immune reactivity prevent excessive inflammation and autoimmunity, but generally dampen antitumor activity. The tumor necrosis factor alpha-induced protein 3 gene encoding the A20 protein, a key molecule controlling NF-\u03baB activation, has been linked to the development of multiple inflammatory pathologies in humans, some of which are recapitulated in mice with selective deletion of A20 in myeloid, dendritic, or B cells. Here, mice with selective deletion of A20 in mature conventional T cells presented no detectable pathology. CD8 T cells from these mice showed increased antigen sensitivity with enhanced production of IL-2 and IFN\u03b3. Importantly, A20-deleted CD8 T cells possessed heightened antitumor activity in vivo. Targeting this gene in adoptively transferred CD8 T cells could represent a promising mechanism to achieve tumor rejection.<\/jats:p>","DOI":"10.1073\/pnas.1406259111","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T01:15:59Z","timestamp":1405386959000},"page":"11115-11120","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":125,"title":["The tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) imposes a brake on antitumor activity of CD8 T cells"],"prefix":"10.1073","volume":"111","author":[{"given":"Marilyn","family":"Giordano","sequence":"first","affiliation":[{"name":"Centre d'Immunologie de Marseille\u2013Luminy, Aix\u2013Marseille University (UM 2), Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1104, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7280, 13288 Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Roncagalli","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille\u2013Luminy, Aix\u2013Marseille University (UM 2), Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1104, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7280, 13288 Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Bourdely","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille\u2013Luminy, Aix\u2013Marseille University (UM 2), Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1104, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7280, 13288 Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Chasson","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille\u2013Luminy, Aix\u2013Marseille University (UM 2), Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1104, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7280, 13288 Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Buferne","sequence":"additional","affiliation":[{"name":"Centre d'Immunologie de Marseille\u2013Luminy, Aix\u2013Marseille University (UM 2), Case 906, 13288 Marseille Cedex 9, France;"},{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, U1104, 13288 Marseille, France;"},{"name":"Centre National de la Recherche Scientifique, Unit\u00e9 Mixte de Recherche 7280, 13288 Marseille, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Division of Molecular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812-8582, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudi","family":"Beyaert","sequence":"additional","affiliation":[{"name":"Department of Biomedical Molecular Biology, Ghent University, B-9052 Ghent, Belgium; 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