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This study took a comprehensive approach to identify the unique transcriptional features of pathogenic Th2 cells with the aim of identifying novel molecular regulators. Highly purified Th1, Th2, Th9, Th17, and Treg cells isolated from mice with allergy, infection, and autoimmunity identified unique mRNA and microRNAs (miRNAs) expressed in Th2 cells. Functional and mechanistic studies using miRNA-deficient mice, luciferase assays, miRNA inhibitors, and siRNA in combination with state-of-the-art adoptive transfer systems, identified a critical role for miR-155\u2013regulated\n                    <jats:italic>S1pr1<\/jats:italic>\n                    in the pathogenesis of Th2-mediated allergy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1406322111","type":"journal-article","created":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T01:15:59Z","timestamp":1405386959000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":124,"title":["Transcriptomics identified a critical role for Th2 cell-intrinsic miR-155 in mediating allergy and antihelminth immunity"],"prefix":"10.1073","volume":"111","author":[{"given":"Isobel S.","family":"Okoye","sequence":"first","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Czieso","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Ktistaki","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Roderick","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Coomes","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria S.","family":"Pelly","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yashaswini","family":"Kannan","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimena","family":"Perez-Lloret","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimmy L.","family":"Zhao","sequence":"additional","affiliation":[{"name":"University of California, Los Angeles, CA 90095; and"},{"name":"California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Baltimore","sequence":"additional","affiliation":[{"name":"California Institute of Technology, Pasadena, CA 91125"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Langhorne","sequence":"additional","affiliation":[{"name":"Parasitology, Medical Research Council, National Institute for Medical Research, London NW7 1AA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Divisions of aMolecular Immunology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,7,14]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.23.021704.115821"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03497.x"},{"key":"e_1_3_3_3_2","first-page":"S4","article-title":"State of world allergy report 2008: Allergy and chronic respiratory diseases","volume":"1","author":"Pawankar R","year":"2008","unstructured":"R Pawankar, et al., State of world allergy report 2008: Allergy and chronic respiratory diseases. 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