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This phenotype, termed \u201c\n                    <jats:italic>supermodel,<\/jats:italic>\n                    \u201d was strictly recessive and was ascribed to a missense mutation in\n                    <jats:italic>Sterile alpha motif domain containing protein 4<\/jats:italic>\n                    (\n                    <jats:italic>Samd4<\/jats:italic>\n                    ), a gene encoding an RNA-binding protein with no previously known function in mammals. This study provides evidence that Samd4 modulates the activities of the mechanistic target of rapamycin complex 1, a master regulator of metabolism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1406511111","type":"journal-article","created":{"date-parts":[[2014,5,6]],"date-time":"2014-05-06T01:45:42Z","timestamp":1399340742000},"page":"7367-7372","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Mutation of mouse\n                    <i>Samd4<\/i>\n                    causes leanness, myopathy, uncoupled mitochondrial respiration, and dysregulated mTORC1 signaling"],"prefix":"10.1073","volume":"111","author":[{"given":"Zhe","family":"Chen","sequence":"first","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Touchstone Diabetes Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Shelton","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aktar","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Zhan","sequence":"additional","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungyong","family":"Won","sequence":"additional","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wataru","family":"Tomisato","sequence":"additional","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hypothalamic Research, University of Texas Southwestern Medical Center, Dallas, TX 75390"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Li","sequence":"additional","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Marie Y.","family":"Moresco","sequence":"additional","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Beutler","sequence":"additional","affiliation":[{"name":"Center for Genetics of Host Defense,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1101\/gad.10.20.2600","article-title":"smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo","volume":"10","author":"Smibert CA","year":"1996","unstructured":"CA Smibert, JE Wilson, K Kerr, PM Macdonald, smaug protein represses translation of unlocalized nanos mRNA in the Drosophila embryo. 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