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These residues are critical in defining the peptide-binding specificity of MHC-I molecules, and they also affect the engagement of MHC-I molecules by killer immunoglobulin-like receptors on natural killer and T cells. These data implicate peptide binding by MHC-I in BD pathogenesis and suggest that altered regulation of cytotoxic cells by MHC-I may be pathogenic in BD.<\/jats:p>","DOI":"10.1073\/pnas.1406575111","type":"journal-article","created":{"date-parts":[[2014,5,13]],"date-time":"2014-05-13T04:53:58Z","timestamp":1399956838000},"page":"8867-8872","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":137,"title":["Beh\u00e7et disease-associated MHC class I residues implicate antigen binding and regulation of cell-mediated cytotoxicity"],"prefix":"10.1073","volume":"111","author":[{"given":"Michael J.","family":"Ombrello","sequence":"first","affiliation":[{"name":"Translational Genetics and Genomics Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Kirino","sequence":"additional","affiliation":[{"name":"Inflammatory Disease Section, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine and Faculty of Medicine, Yokohama City 236-0004, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I. 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