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Here, we describe novel probes, derived from a tarantula venom peptide, that are able to report the activity of voltage-gated ion channels in living cells. This technology uses state-selective binding to optically monitor the activation of ion channels during cellular electrical signaling. Activity-reporting probes based on these prototypes could potentially identify when endogenous ion channels contribute to electrical signaling, thus facilitating the identification of ion channel targets for therapeutic drug intervention.<\/jats:p>","DOI":"10.1073\/pnas.1406876111","type":"journal-article","created":{"date-parts":[[2014,10,21]],"date-time":"2014-10-21T02:45:44Z","timestamp":1413859544000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":46,"title":["Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells"],"prefix":"10.1073","volume":"111","author":[{"given":"Drew C.","family":"Tilley","sequence":"first","affiliation":[{"name":"Department of Physiology and Membrane Biology, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Eum","sequence":"additional","affiliation":[{"name":"Department of 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