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Here, realistically concentrated solutions of a prevalent eye lens structural protein, \u03b1-crystallin, which exhibits short-range order needed for lens transparency, are found in addition to show high-concentration dynamical slowing down similar to that of hard-sphere glass transitions. This suggests that analogous investigation of concentrated crystallin mixtures, like those in the living lens, may help to advance understanding of the molecular basis of both presbyopia and cataract.<\/jats:p>","DOI":"10.1073\/pnas.1406990111","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T23:42:34Z","timestamp":1415662954000},"page":"16748-16753","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":64,"title":["Hard sphere-like glass transition in eye lens \u03b1-crystallin solutions"],"prefix":"10.1073","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7444-1453","authenticated-orcid":false,"given":"Giuseppe","family":"Foffi","sequence":"first","affiliation":[{"name":"Laboratoire de Physique de Solides, UMR 8502, Universit\u00e9 Paris-Sud, F-91405 Orsay, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Savin","sequence":"additional","affiliation":[{"name":"Physics Department and Fribourg Center for Nanomaterials, University of Fribourg, CH-1700 Fribourg, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Bucciarelli","sequence":"additional","affiliation":[{"name":"Physical Chemistry, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Dorsaz","sequence":"additional","affiliation":[{"name":"Institute of Theoretical Physics, Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne, CH-1015 Lausanne, Switzerland; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M.","family":"Thurston","sequence":"additional","affiliation":[{"name":"School of Physics and Astronomy, Rochester Institute of Technology, Rochester, NY 14623-5603"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Stradner","sequence":"additional","affiliation":[{"name":"Physical Chemistry, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schurtenberger","sequence":"additional","affiliation":[{"name":"Physical Chemistry, Department of Chemistry, Lund University, SE-221 00 Lund, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1364\/AO.10.000459"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/302415a0"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1063\/1.2168451"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.99.198103"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp807103f"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1039\/C0SM00156B"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014653107"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1039\/C0SM01175D"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1021\/jp112180p"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.21.10449"},{"key":"e_1_3_3_11_2","first-page":"713","article-title":"Molecular basis of eye lens transparency. 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