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T cells provide therapeutic benefit by directly inducing cell lysis and shaping the immune response through soluble proteins (cytokines) critical for intervening in cancer and viral infection. Here, we demonstrate that subunit vaccines are uniquely and unexpectedly dependent on the cytokine IL-27 for making strong T-cell responses.<\/jats:p>","DOI":"10.1073\/pnas.1407393111","type":"journal-article","created":{"date-parts":[[2014,9,30]],"date-time":"2014-09-30T11:28:38Z","timestamp":1412076518000},"page":"16472-16477","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":66,"title":["IL-27 is required for shaping the magnitude, affinity distribution, and memory of T cells responding to subunit immunization"],"prefix":"10.1073","volume":"111","author":[{"given":"Nathan D.","family":"Pennock","sequence":"first","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Gapin","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross M.","family":"Kedl","sequence":"additional","affiliation":[{"name":"Department of Immunology and Microbiology, University of Colorado Denver, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,9,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091279"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/30996"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.4049\/jimmunol.162.6.3256","article-title":"Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells","volume":"162","author":"Curtsinger JM","year":"1999","unstructured":"JM Curtsinger, , Inflammatory cytokines provide a third signal for activation of naive CD4+ and CD8+ T cells. 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