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In this study, we demonstrate that the developing relationships between default mode network (DMN) and task positive networks (TPNs) exhibit significant and specific maturational lag in ADHD. Previous research has found that individuals with ADHD exhibit abnormalities in DMN\u2013TPN relationships. Our results provide strong initial evidence that these alterations arise from delays in typical maturational patterns. Our results invite further investigation into the neurobiological mechanisms in ADHD that produce delays in development of large-scale networks.<\/jats:p>","DOI":"10.1073\/pnas.1407787111","type":"journal-article","created":{"date-parts":[[2014,9,16]],"date-time":"2014-09-16T04:31:40Z","timestamp":1410841900000},"page":"14259-14264","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":193,"title":["Lag in maturation of the brain\u2019s intrinsic functional architecture in attention-deficit\/hyperactivity disorder"],"prefix":"10.1073","volume":"111","author":[{"given":"Chandra S.","family":"Sripada","sequence":"first","affiliation":[{"name":"Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Angstadt","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,9,15]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.59.8.1244"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2003.tb02531.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707741104"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0710329105"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.14.1740"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.5.540"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.01.031"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2013.04.007"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0504136102"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2011.09.006"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705843104"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800376105"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000381"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2011.0007"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000157"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2010.04.009"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.09.015"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2010.07.003"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2007.02.005"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.007"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.676"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1440.011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.11.003"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2007.11.031"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2006.02.022"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2007.06.025"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22504"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2010.04.004"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.07.008"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.04.083"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.21058"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705843104"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-3235-1"},{"key":"e_1_3_3_34_2","first-page":"62","article-title":"The ADHD-200 Consortium: A model to advance the translational potential of neuroimaging in clinical neuroscience","volume":"6","author":"HD-200 Consortium","year":"2012","unstructured":"; HD-200 Consortium, The ADHD-200 Consortium: A model to advance the translational potential of neuroimaging in clinical neuroscience. 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