{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:44:09Z","timestamp":1793018649256,"version":"4.5.0"},"reference-count":23,"publisher":"National Academy of Sciences","issue":"23","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,6,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Genetic linkage to major histocompatibility complex class II proteins has been observed in many immunological disorders; yet, little is known about the underlying mechanisms of these associations. For chronic beryllium disease (CBD), the linkage to\n                    <jats:italic>HLA-DPB1<\/jats:italic>\n                    alleles encoding a glutamic acid at position 69 of the \u03b2-chain is well established. We tested whether the presence of HLA-DP2 is sufficient for the development of a disease-specific model of CBD. HLA-DP2 transgenic mice developed a beryllium-specific adaptive immune response composed of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T cells that secrete Th1-type cytokines and are HLA-DP2-restricted, thus replicating the major features of the human disease. In addition, regulatory T cells modulate granuloma formation in the lungs of beryllium oxide-exposed HLA-DP2 transgenic mice.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1408048111","type":"journal-article","created":{"date-parts":[[2014,5,28]],"date-time":"2014-05-28T02:22:54Z","timestamp":1401243774000},"page":"8553-8558","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Regulatory T cells modulate granulomatous inflammation in an HLA-DP2 transgenic murine model of beryllium-induced disease"],"prefix":"10.1073","volume":"111","author":[{"given":"Douglas G.","family":"Mack","sequence":"first","affiliation":[{"name":"Departments of aMedicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Falta","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"McKee","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison K.","family":"Martin","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip L.","family":"Simonian","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frances","family":"Crawford","sequence":"additional","affiliation":[{"name":"Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;"},{"name":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Gordon","sequence":"additional","affiliation":[{"name":"Department of Environmental Medicine, New York University, Tuxedo, NY 10987;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert R.","family":"Mercer","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Hoover","sequence":"additional","affiliation":[{"name":"National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, WV 26505; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippa","family":"Marrack","sequence":"additional","affiliation":[{"name":"Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;"},{"name":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Kappler","sequence":"additional","affiliation":[{"name":"Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;"},{"name":"Howard Hughes Medical Institute, National Jewish Health, Denver, CO 80206"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubin M.","family":"Tuder","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Fontenot","sequence":"additional","affiliation":[{"name":"Departments of aMedicine and"},{"name":"Immunology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,5,27]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.08.004"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwg001"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.220430797"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.5.3549"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1001772107"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80856-9"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.18.1.423"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0025OC"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/15476910902977399"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.08.022"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.01.019"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20122426"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.10.7029"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00232"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091885"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-6111-1_9"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120822"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120914"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00253"},{"key":"e_1_3_3_20_2","volume-title":"Manipulating the Mouse Embryo: A Laboratory Manual","author":"Hogan B","year":"1986","unstructured":"B Hogan, F Costantini, E Lacy Manipulating the Mouse Embryo: A Laboratory Manual (Cold Spring Harbor Lab Press, Cold Spring Harbor, NY, 1986)."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/15428110308984820"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/ac802251n"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1080\/15287390306417"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1408048111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:01:55Z","timestamp":1649804515000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1408048111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,5,27]]},"references-count":23,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2014,6,10]]}},"alternative-id":["10.1073\/pnas.1408048111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1408048111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,5,27]]},"assertion":[{"value":"2014-05-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}