{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:44:39Z","timestamp":1790163879382,"version":"4.1.0"},"reference-count":44,"publisher":"National Academy of Sciences","issue":"24","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,6,17]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Lassa virus is, after dengue virus, the second most common cause of viral hemorrhagic fever. In susceptible individuals, Lassa virus infection is associated with vascular permeability, leading to tissue edema, organ failure, and death. Hemorrhagic fever viruses efficiently infect vascular endothelial cells, but are generally considered noncytopathic. Thus, the mechanism of virus-induced vascular injury remains unclear. Using the lymphocytic choriomeningitis virus variant clone 13, a prototype of Lassa virus, we show here that lethal vascular leakage in susceptible mice was completely prevented by type I IFN receptor blockade. Therefore, approaches that target type I IFNs or effector molecules induced by these cytokines may be considered for the treatment of Lassa fever and other severe hemorrhagic viral illnesses.<\/jats:p>","DOI":"10.1073\/pnas.1408148111","type":"journal-article","created":{"date-parts":[[2014,6,3]],"date-time":"2014-06-03T02:56:28Z","timestamp":1401764188000},"page":"8925-8930","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":72,"title":["Type I interferon is a therapeutic target for virus-induced lethal vascular damage"],"prefix":"10.1073","volume":"111","author":[{"given":"Roberto","family":"Baccala","sequence":"first","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan J.","family":"Welch","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana","family":"Gonzalez-Quintial","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin B.","family":"Walsh","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Teijaro","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cherie T.","family":"Ng","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Zarpellon","sequence":"additional","affiliation":[{"name":"Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaverio M.","family":"Ruggeri","sequence":"additional","affiliation":[{"name":"Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"de la Torre","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Argyrios N.","family":"Theofilopoulos","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B. A.","family":"Oldstone","sequence":"additional","affiliation":[{"name":"Departments of aImmunology and Microbial Science and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,6,2]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"75","article-title":"Lassa fever","volume":"262","author":"McCormick JB","year":"2002","unstructured":"JB McCormick, SP Fisher-Hoch, Lassa fever. Curr Top Microbiol Immunol 262, 75\u2013109 (2002).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_2_2","first-page":"1","article-title":"Lassa fever in West African sub-region: An overview","volume":"44","author":"Ogbu O","year":"2007","unstructured":"O Ogbu, E Ajuluchukwu, CJ Uneke, Lassa fever in West African sub-region: An overview. J Vector Borne Dis 44, 1\u201311 (2007).","journal-title":"J Vector Borne Dis"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.3390\/v4112766"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-020712-164041"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.09.028"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002406"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2079"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.003"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.22.14282-14296.2005"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2010.11.023"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.9.1249"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.160.2.521"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.5.1719"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011998107"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019304108"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/70938"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.4.1863-1869.1991"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2013.04.010"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900088106"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1492"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061462"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04444"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2035"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235214"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1235208"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20121015"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1125676"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00155-10"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103656"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.017"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.04.016"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2012.05.003"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1297"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.185.3.517"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0711200105"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-125906"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000847"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-06-0357"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040769"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20101664"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000836"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2003.12.013"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/nri2171"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1201477"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1408148111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:34:09Z","timestamp":1649806449000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1408148111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,2]]},"references-count":44,"journal-issue":{"issue":"24","published-print":{"date-parts":[[2014,6,17]]}},"alternative-id":["10.1073\/pnas.1408148111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1408148111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,2]]},"assertion":[{"value":"2014-06-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}