{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T13:52:26Z","timestamp":1792245146154,"version":"4.4.0"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"32","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,8,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Intrinsic bursts and rhythmic burst discharges are elicited by activation of T-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels in the thalamic reticular nucleus (TRN). TRN bursts are believed to be critical for generation and maintenance of thalamocortical oscillations, leading to spike-and-wave discharges (SWDs) on the cortical electroencephalogram, which are the hallmarks of absence seizures. Using knockout mice for T-type Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels that completely lack TRN bursts, however, we show that increased tonic firing in the TRN seems sufficient for drug-induced SWD generation. These results call into question the role of burst firing in TRN neurons in the genesis of SWDs, calling for a rethinking of the mechanism for absence seizure induction.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1408609111","type":"journal-article","created":{"date-parts":[[2014,7,29]],"date-time":"2014-07-29T02:39:50Z","timestamp":1406601590000},"page":"11828-11833","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":60,"title":["Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice"],"prefix":"10.1073","volume":"111","author":[{"given":"Seung Eun","family":"Lee","sequence":"first","affiliation":[{"name":"Center for Cognition and Sociality, Institute for Basic Science, Daejeon 305-811, Korea;"},{"name":"Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;"},{"name":"Laboratory of Cell Death and Human Diseases, Department of Life Sciences, School of Life Sciences, Korea University, Seoul 136-701, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaekwang","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Functional Connectomics, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Latchoumane","sequence":"additional","affiliation":[{"name":"Center for Cognition and Sociality, Institute for Basic Science, Daejeon 305-811, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Center for Cognition and Sociality, Institute for Basic Science, Daejeon 305-811, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo-Jin","family":"Oh","sequence":"additional","affiliation":[{"name":"Center for Neural Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahangir Alam","family":"Saud","sequence":"additional","affiliation":[{"name":"Center for Neural Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheongdahm","family":"Park","sequence":"additional","affiliation":[{"name":"Center for Neural Science, Brain Science Institute, Korea Institute of Science and Technology, Seoul 136-791, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Protein Sciences, Amgen, Inc., Thousand Oaks, CA 91320;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunji","family":"Cheong","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Chang","family":"Chen","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, Academia Sinica, Nankang, Taipei 115, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Ju","family":"Choi","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Death and Human Diseases, Department of Life Sciences, School of Life Sciences, Korea University, Seoul 136-701, Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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