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A survey of cancer tissue banks reveals that ZAP is commonly deficient in human cancers, suggesting extensive application prospects of M1. Our work provides an example of a potentially personalized cancer therapy using a targeted oncolytic virus that can be selectively administered to patients with ZAP-deficient tumors. We predict that such agents will form the armamentarium of cancer therapy in the future.<\/jats:p>","DOI":"10.1073\/pnas.1408759111","type":"journal-article","created":{"date-parts":[[2014,10,6]],"date-time":"2014-10-06T22:54:30Z","timestamp":1412636070000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":150,"title":["Identification and characterization of alphavirus M1 as a selective oncolytic virus targeting ZAP-defective human cancers"],"prefix":"10.1073","volume":"111","author":[{"given":"Yuan","family":"Lin","sequence":"first","affiliation":[{"name":"Departments of aPharmacology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haipeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiankai","family":"Liang","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbo","family":"Zhu","sequence":"additional","affiliation":[{"name":"Departments of aPharmacology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liwu","family":"Fu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou 510060, China; 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