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We found that mice lacking endothelin receptor A (ET\n                    <jats:sub>A<\/jats:sub>\n                    ) only in sympathetic neurons but not in cardiomyocytes were protected from the development of HF. Mechanistically, the presynaptic reuptake of NE within the heart was preserved in mice lacking ET\n                    <jats:sub>A<\/jats:sub>\n                    only in sympathetic neurons. These data provide an explanation of why patients in clinical studies do not benefit from ET1 receptor antagonists, because these patients are usually treated with \u03b2 blockers, which interfere with the mechanism of action identified here.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1409026111","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T23:56:19Z","timestamp":1409702179000},"page":"13499-13504","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["Essential role of sympathetic endothelin A receptors for adverse cardiac remodeling"],"prefix":"10.1073","volume":"111","author":[{"given":"Lorenz H.","family":"Lehmann","sequence":"first","affiliation":[{"name":"Research Unit Cardiac Epigenetics, Department of Cardiology, University of Heidelberg, D-69120 Heidelberg, Germany;"},{"name":"DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg\/Mannheim, 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