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We describe how segregating genetic variation in pigmentation phenotypes has reached fixation within a single breed, and also highlight the genomic differences between domestic cats and wildcats. Specifically, the signatures of selection in the domestic cat genome are linked to genes associated with gene knockout models affecting memory, fear-conditioning behavior, and stimulus-reward learning, and potentially point to the processes by which cats became domesticated.<\/jats:p>","DOI":"10.1073\/pnas.1410083111","type":"journal-article","created":{"date-parts":[[2014,11,10]],"date-time":"2014-11-10T23:42:34Z","timestamp":1415662954000},"page":"17230-17235","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":307,"title":["Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication"],"prefix":"10.1073","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0253-4404","authenticated-orcid":false,"given":"Michael J.","family":"Montague","sequence":"first","affiliation":[{"name":"The Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&amp;M University, College Station, TX 77843;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Gandolfi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine &amp; Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Razib","family":"Khan","sequence":"additional","affiliation":[{"name":"Population Health &amp; Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwen L.","family":"Aken","sequence":"additional","affiliation":[{"name":"Wellcome Trust Sanger Institute, Hinxton CB10 1SA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M. 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C.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University, Bloomington, IN 47405;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew W.","family":"Hahn","sequence":"additional","affiliation":[{"name":"Department of Biology, Indiana University, Bloomington, IN 47405;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn","family":"Menotti-Raymond","sequence":"additional","affiliation":[{"name":"Laboratory of Genomic Diversity, Center for Cancer Research, Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen J.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University, St. Petersburg 199178, Russia; and"},{"name":"Oceanographic Center, Nova Southeastern University, Fort Lauderdale, FL 33314"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Wilson","sequence":"additional","affiliation":[{"name":"The Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie A.","family":"Lyons","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine &amp; Surgery, College of Veterinary Medicine, University of Missouri, Columbia, MO 65201;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William J.","family":"Murphy","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine, Texas A&amp;M University, College Station, TX 77843;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley C.","family":"Warren","sequence":"additional","affiliation":[{"name":"The Genome Institute, Washington University School of Medicine, St. Louis, MO 63108;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,11,10]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"National Pet Owner\u2019s Survey","author":"American Pet Product Manufacturing Association","year":"2008","unstructured":"; American Pet Product Manufacturing Association National Pet Owner\u2019s Survey (Am Pet Prod Manuf Assoc, Greenwich, CT, 2008)."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1126\/science.1211028","article-title":"Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on mammal diversification","volume":"334","author":"Meredith RW","year":"2011","unstructured":"RW Meredith, , Impacts of the Cretaceous Terrestrial Revolution and KPg extinction on mammal diversification. 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