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We report a modular approach to build such models, validated by a framework model of\n                    <jats:italic>Arabidopsis thaliana<\/jats:italic>\n                    comprising four existing mathematical models. Our model brings together gene dynamics, carbon partitioning, organ growth, shoot architecture, and development in response to environmental signals. It predicted the biomass of each leaf in independent data, demonstrated flexible control of photosynthesis across photoperiods, and predicted the pleiotropic phenotype of a developmentally misregulated transgenic line. Systems biology, crop science, and ecology might thus be linked productively in a community-based approach to modeling.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1410238111","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T23:56:19Z","timestamp":1409702179000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":95,"title":["Multiscale digital\n                    <i>Arabidopsis<\/i>\n                    predicts individual organ and whole-organism growth"],"prefix":"10.1073","volume":"111","author":[{"given":"Yin Hoon","family":"Chew","sequence":"first","affiliation":[{"name":"SynthSys and School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9n\u00e9dicte","family":"Wenden","sequence":"additional","affiliation":[{"name":"Institut National de la Recherche Agronomique and Universit\u00e9 Bordeaux, Unit\u00e9 Mixte de Recherche 1332 de Biologie du Fruit et Pathologie, F-33140 Villenave d\u2019Ornon, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Flis","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginie","family":"Mengin","sequence":"additional","affiliation":[{"name":"Max Planck Institute of Molecular Plant Physiology, 14476 Potsdam-Golm, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper","family":"Taylor","sequence":"additional","affiliation":[{"name":"Simulistics Ltd., Loanhead EH20 9PA, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher L.","family":"Davey","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 2FG, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Tindal","sequence":"additional","affiliation":[{"name":"SynthSys and School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Thomas","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 2FG, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen J.","family":"Ougham","sequence":"additional","affiliation":[{"name":"Institute of Biological, Environmental and Rural Sciences, Aberystwyth University, Aberystwyth SY23 2FG, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"de Reffye","sequence":"additional","affiliation":[{"name":"Cirad-Amis, Unit\u00e9 Mixte de Recherche, botAnique et bioinforMatique de l'Architecture des Plantes, F-34398 Montpellier Cedex 5, France; 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