{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:44:00Z","timestamp":1793033040213,"version":"4.5.0"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"32","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,8,12]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Allergic asthma represents an increasingly common public health problem. Here, we provide preclinical evidence for the efficacy of active tolerization using\n                    <jats:italic>Helicobacter pylori<\/jats:italic>\n                    components as a viable strategy for asthma prevention. We use a mouse model of allergic asthma to show that regular treatment with\n                    <jats:italic>H. pylori<\/jats:italic>\n                    extract effectively alleviates all hallmarks of the disease. Successful treatment depends on the regulatory cytokine IL-10 and on basic leucine zipper ATF-like 3 (BATF3)-dependent dendritic cell lineages.\n                    <jats:italic>H. pylori<\/jats:italic>\n                    extracts lacking the \u03b3-glutamyl-transpeptidase GGT or the vacuolating cytotoxin VacA fail to protect against asthma; conversely, both factors can be administered in purified form to achieve protection. In conclusion, the immunomodulatory properties of the common infectious agent\n                    <jats:italic>H. pylori<\/jats:italic>\n                    can be exploited for therapeutic purposes in an allergy model.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1410579111","type":"journal-article","created":{"date-parts":[[2014,7,30]],"date-time":"2014-07-30T00:48:59Z","timestamp":1406681339000},"page":"11810-11815","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":111,"title":["Effective treatment of allergic airway inflammation with\n                    <i>Helicobacter pylori<\/i>\n                    immunomodulators requires BATF3-dependent dendritic cells and IL-10"],"prefix":"10.1073","volume":"111","author":[{"given":"Daniela B.","family":"Engler","sequence":"first","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Reuter","sequence":"additional","affiliation":[{"name":"Medical Clinic III and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda","family":"van Wijck","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Urban","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Kyburz","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Maxeiner","sequence":"additional","affiliation":[{"name":"Medical Clinic III and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Martin","sequence":"additional","affiliation":[{"name":"Medical Clinic III and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nir","family":"Yogev","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, Johannes Gutenberg University, 55131 Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Waisman","sequence":"additional","affiliation":[{"name":"Institute for Molecular Medicine, Johannes Gutenberg University, 55131 Mainz, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Gerhard","sequence":"additional","affiliation":[{"name":"Institute of Microbiology, Immunology and Hygiene, Technical University of Munich and German Center for Infection Research, 81675 Munich, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy L.","family":"Cover","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine and Veterans Affairs Tennessee Valley Healthcare System, Nashville, TN 37232-2358"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Taube","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Leiden University Medical Center, 2333 ZA, Leiden, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Molecular Cancer Research, University of Z\u00fcrich, 8057 Z\u00fcrich, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,7,29]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra054308"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2245"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.299.6710.1259"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03831.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.167.8.821"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1086\/590158"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004060"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2006.046706"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45041"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI61029"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3016"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91816-6"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199110173251603"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.02.066"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002269"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2010.06.047"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.7.3782"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091627"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1211248110"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.53.37736"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.06.002"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103212"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01271.x"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)50054-0"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.138.4.759"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1410579111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:42:00Z","timestamp":1649803320000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1410579111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,29]]},"references-count":25,"journal-issue":{"issue":"32","published-print":{"date-parts":[[2014,8,12]]}},"alternative-id":["10.1073\/pnas.1410579111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1410579111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,29]]},"assertion":[{"value":"2014-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}