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Here we show how a particularly disordered region of cardiac troponin I impacts the overall global conformation and function of its binding partner, cardiac troponin C. This newly described role for an IDR is accomplished through electrostatic interactions, which are particularly suited to IDRs. The regulation of electrostatic interactions in IDRs through phosphorylation is an emerging concept in cellular signaling, and troponin I is now another important example, one known by cardiac physiologists for 40 y.<\/jats:p>","DOI":"10.1073\/pnas.1410775111","type":"journal-article","created":{"date-parts":[[2014,9,23]],"date-time":"2014-09-23T03:21:36Z","timestamp":1411442496000},"page":"14412-14417","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":59,"title":["The cardiac-specific N-terminal region of troponin I positions the regulatory domain of troponin C"],"prefix":"10.1073","volume":"111","author":[{"given":"Peter M.","family":"Hwang","sequence":"first","affiliation":[{"name":"Division of General Internal Medicine, Department of Medicine, and"},{"name":"Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangze","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra E.","family":"Pineda-Sanabria","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Corson","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian D.","family":"Sykes","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada T6G 2H7"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,9,22]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1161\/CIRCRESAHA.115.302922","article-title":"Heart failure with preserved ejection fraction: Mechanisms, clinical features, and therapies","volume":"115","author":"Sharma K","year":"2014","unstructured":"K Sharma, DA Kass, Heart failure with preserved ejection fraction: Mechanisms, clinical features, and therapies. 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