{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:21:51Z","timestamp":1791210111538,"version":"4.1.0"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"14","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2001,7,3]]},"abstract":"<jats:p>\n                    The daily rhythm in melatonin levels is controlled by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine\n                    <jats:italic>N<\/jats:italic>\n                    -acetyltransferase (AANAT; serotonin\n                    <jats:italic>N<\/jats:italic>\n                    -acetyltransferase, EC\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"ec\" xlink:href=\"2.3.1.87\">2.3.1.87<\/jats:ext-link>\n                    ). Results presented here describe a regulatory\/binding sequence in AANAT that encodes a cAMP-operated binding switch through which cAMP-regulated protein kinase-catalyzed phosphorylation [RRHTLPAN \u2192 RRHpTLPAN] promotes formation of a complex with 14-3-3 proteins. Formation of this AANAT\/14-3-3 complex enhances melatonin production by shielding AANAT from dephosphorylation and\/or proteolysis and by decreasing the\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>m<\/jats:sub>\n                    for 5-hydroxytryptamine (serotonin). Similar switches could play a role in cAMP signal transduction in other biological systems.\n                  <\/jats:p>","DOI":"10.1073\/pnas.141118798","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T10:37:36Z","timestamp":1027679856000},"page":"8083-8088","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":157,"title":["Role of a pineal cAMP-operated arylalkylamine\n                    <i>N-<\/i>\n                    acetyltransferase\/14-3-3-binding switch in melatonin synthesis"],"prefix":"10.1073","volume":"98","author":[{"given":"Surajit","family":"Ganguly","sequence":"first","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan A.","family":"Gastel","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan L.","family":"Weller","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Schwartz","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Jaffe","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. A. A.","family":"Namboodiri","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Coon","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison B.","family":"Hickman","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rollag","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomas","family":"Obsil","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Beauverger","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Ferry","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; Protein Sequencing Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892; Circadian Research Center, Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD 20814; and Laboratory of Molecular..."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean A.","family":"Boutin","sequence":"additional","affiliation":[{"name":"Section on Neuroendocrinology, Laboratory of Developmental Neurobiology, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-4480; 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