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This assay is easily applied to human brain homogenates and selectively responds to Alzheimer's disease but not Huntington's disease brains. By comparing seeding activity in a mouse model of human tauopathy, we demonstrate detection of proteopathic seeding far in advance of standard histopathological markers. Proteopathic seeding is thus an early marker of tauopathy, consistent with a causal role for tau seeds in neurodegeneration.<\/jats:p>","DOI":"10.1073\/pnas.1411649111","type":"journal-article","created":{"date-parts":[[2014,9,26]],"date-time":"2014-09-26T23:25:39Z","timestamp":1411773939000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":692,"title":["Proteopathic tau seeding predicts tauopathy in vivo"],"prefix":"10.1073","volume":"111","author":[{"given":"Brandon B.","family":"Holmes","sequence":"first","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer\u2019s Disease Research Center, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Furman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Hope Center for Neurological Disorders, Knight Alzheimer\u2019s Disease Research Center, 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