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The autoantigen was identified as the common C-terminal epitope of neuropeptide glutamic acid-isoleucine\/\u03b1\u2013melanocyte-stimulating hormone (NEI\/\u03b1MSH). Purified IgGs from a patient with MCH\/POMC staining injected intracerebroventricularly to rats caused disturbed sleep patterns. Also, GABAergic cortical interneurons were stained with other narcolepsy and OSRD sera. Thus, autoantibodies are frequent in patients with sleep disorders, and NEI\/\u03b1MSH may be a previously unidentified autoantigen involved in pathomechanism(s). These findings indicate possible diagnostic\/therapeutic targets.<\/jats:p>","DOI":"10.1073\/pnas.1412189111","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T02:18:04Z","timestamp":1408414684000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":75,"title":["Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns"],"prefix":"10.1073","volume":"111","author":[{"given":"Peter","family":"Bergman","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, 14186 Stockholm, Sweden;"},{"name":"Department of Medicine, Center for Infectious Medicine (CIM), Karolinska Institutet and Karolinska University Hospital, 14186 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csaba","family":"Adori","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Karolinska Institutet, 1711 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Szilvia","family":"Vas","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 1089, Budapest, Hungary;"},{"name":"Hungarian Academy of Sciences (MTA)--Semmelweis University (SE) Neuropsychopharmacology and Neurochemistry Research Group, 1089 Budapest, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ylva","family":"Kai-Larsen","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, 14186 Stockholm, Sweden;"},{"name":"Department of Neuroscience, Karolinska Institutet, 1711 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi","family":"Sarkanen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Central Finland Hospital, 40620 Jyv\u00e4skyl\u00e4, Finland;"},{"name":"Helsinki Sleep Clinic, Vitalmed Research Centre, 00420 Helsinki, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Cederlund","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 17177 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgitta","family":"Agerberth","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet and Karolinska University Hospital, 14186 Stockholm, Sweden;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilkka","family":"Julkunen","sequence":"additional","affiliation":[{"name":"Department of Virology, University of Turku, 20520 Turku, Finland;"},{"name":"Virology Unit, National Institute for Health and Welfare (THL), 00300 Helsinki, Finland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beata","family":"Horvath","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 1089, Budapest, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Kostyalik","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics, Semmelweis University, 1089, Budapest, Hungary;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Kalm\u00e1r","sequence":"additional","affiliation":[{"name":"Institute of Enzymology, Research Centre for Natural Sciences, Hungarian Academy of Sciences, 1117 Budapest, Hungary; 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