{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:15:32Z","timestamp":1790248532421,"version":"4.1.0"},"reference-count":51,"publisher":"National Academy of Sciences","issue":"48","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,12,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Gastrointestinal worms (helminths) infect more than 2 billion people, and vaccines are not yet available. Helminths elicit a type 2 immune response characterized by high serum IgE levels and increased numbers of IL-4\u2013 or IL-13\u2013secreting effector cells including Th2 cells, eosinophils, basophils, and type 2 innate lymphoid cells. We determined the mechanism by which basophils contribute to protection against secondary infections with gastrointestinal helminths. Here we demonstrate that basophils are recruited into the small intestine of infected mice and orchestrate the local type 2 immune response in this tissue. Basophil-mediated protection required the presence of IgE and the expression of activating Fc receptors and IL-4\/IL-13 in basophils. These findings could help the development of new vaccination strategies against helminths.<\/jats:p>","DOI":"10.1073\/pnas.1412663111","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T03:43:24Z","timestamp":1416455004000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion"],"prefix":"10.1073","volume":"111","author":[{"given":"Christian","family":"Schwartz","sequence":"first","affiliation":[{"name":"Department of Infection Biology, Universit\u00e4tsklinikum Erlangen, 91054 Erlangen, Germany;"},{"name":"Department of Biology, Friedrich Alexander University Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Turqueti-Neves","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, Universit\u00e4tsklinikum Erlangen, 91054 Erlangen, Germany;"},{"name":"Department of Biology, Friedrich Alexander University Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Freie Universit\u00e4t Berlin, 14163 Berlin, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Yu","sequence":"additional","affiliation":[{"name":"Institute for Immunology, Philipps-University Marburg, 35032 Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falk","family":"Nimmerjahn","sequence":"additional","affiliation":[{"name":"Department of Biology, Friedrich Alexander University Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Voehringer","sequence":"additional","affiliation":[{"name":"Department of Infection Biology, Universit\u00e4tsklinikum Erlangen, 91054 Erlangen, Germany;"},{"name":"Department of Biology, Friedrich Alexander University Erlangen-N\u00fcrnberg, 91058 Erlangen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,11,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68653-4"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1179\/136485909X398212"},{"key":"e_1_3_3_3_2","unstructured":"M Camberis G Le Gros Jr J Urban Animal model of Nippostrongylus brasiliensis and Heligmosomoides polygyrus. Curr Protoc Immunol Chapter 19:Unit 19.12.2\u201319.12.27. (2003)."},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182000059758"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature08900"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1112268109"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.2013.109"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1200968"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040590"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2835"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.2.1063"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2036"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.08.011"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42680"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1883"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.11.014"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20130761"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117584109"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1740"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.15.1.505"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4894(91)90074-7"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.13.5513"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1451"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2008.08.014"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001703"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2009.01.006"},{"key":"e_1_3_3_27_2","first-page":"405","article-title":"Immune mechanisms to Ascaris suum in inbred guinea-pigs. I. Passive transfer of immunity by cells or serum","volume":"32","author":"Khoury PB","year":"1977","unstructured":"PB Khoury, BE Stromberg, EJ Soulsby, Immune mechanisms to Ascaris suum in inbred guinea-pigs. I. Passive transfer of immunity by cells or serum. Immunology 32, 405\u2013411 (1977).","journal-title":"Immunology"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1979.tb00692.x"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1983.4"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-05-154773"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00186-8"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040598"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1621"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002319"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20091268"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242675"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2010.11.005"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.484-489.1999"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1086\/339005"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1002\/eji.1830220622"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-06-027490"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901841"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000940"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2007.04.006"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.10.5315-5323.1999"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00502-09"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1341"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.189.10.1565"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1038\/370367a0"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90115-5"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)00027-3"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1412663111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T23:53:39Z","timestamp":1649807619000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1412663111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,17]]},"references-count":51,"journal-issue":{"issue":"48","published-print":{"date-parts":[[2014,12,2]]}},"alternative-id":["10.1073\/pnas.1412663111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1412663111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,17]]},"assertion":[{"value":"2014-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}