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We demonstrate for a proof-of-principle case that structure-guided U2AF\n                    <jats:sup>65<\/jats:sup>\n                    variants are a feasible tool to evoke disease-relevant changes in pre-mRNA splicing.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1412743111","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T23:48:51Z","timestamp":1416872931000},"page":"17420-17425","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":17,"title":["Structure-guided U2AF\n                    <sup>65<\/sup>\n                    variant improves recognition and splicing of a defective pre-mRNA"],"prefix":"10.1073","volume":"111","author":[{"given":"Anant A.","family":"Agrawal","sequence":"first","affiliation":[{"name":"Center for RNA Biology and Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krystle J.","family":"McLaughlin","sequence":"additional","affiliation":[{"name":"Center for RNA Biology and Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jermaine L.","family":"Jenkins","sequence":"additional","affiliation":[{"name":"Center for RNA Biology and Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara L.","family":"Kielkopf","sequence":"additional","affiliation":[{"name":"Center for RNA Biology and Department of Biochemistry and Biophysics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"525","volume-title":"The RNA World","author":"Burge CB","year":"1999","unstructured":"CB Burge, T Tuschl, CB Burge, PA Sharp, Splicing of precursors to mRNAs by the spliceosomes. 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