{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:12:37Z","timestamp":1789578757129,"version":"build-2803163510"},"reference-count":55,"publisher":"National Academy of Sciences","issue":"37","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,9,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Inflammatory bowel diseases (IBDs) are debilitating conditions with no known cure. Recent evidence suggests that elevated intestinal hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S) synthesis promotes healing and reduces inflammation. H\n                    <jats:sub>2<\/jats:sub>\n                    S is synthesized from cysteine largely via vitamin B\n                    <jats:sub>6<\/jats:sub>\n                    -dependent enzymes. People with IBD are also at increased risk of hyperhomocysteinemia, a condition that is often caused by vitamin B deficiency. Dietary induction of vitamin B deficiency markedly increased serum homocysteine levels and worsened colitis in rodents. The latter was due to the absence of the typical injury-induced elevation of H\n                    <jats:sub>2<\/jats:sub>\n                    S synthesis. Interleukin-10 plays a key role in increasing H\n                    <jats:sub>2<\/jats:sub>\n                    S synthesis, attenuating the severity of colitis, and reducing serum homocysteine levels. The H\n                    <jats:sub>2<\/jats:sub>\n                    S\u2013interleukin 10 axis may be a viable target for therapy of IBD.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1413390111","type":"journal-article","created":{"date-parts":[[2014,9,4]],"date-time":"2014-09-04T16:37:23Z","timestamp":1409848643000},"page":"13559-13564","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":90,"title":["Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis"],"prefix":"10.1073","volume":"111","author":[{"given":"Kyle L.","family":"Flannigan","sequence":"first","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence A.","family":"Agbor","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory W.","family":"Blackler","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice J.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waliul I.","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena F.","family":"Verdu","sequence":"additional","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, ON, Canada L8S 4L8;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G. 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