{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:41:54Z","timestamp":1792104114877,"version":"4.4.0"},"reference-count":37,"publisher":"National Academy of Sciences","issue":"52","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,12,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    T\n                    <jats:sub>H<\/jats:sub>\n                    17 cells are a subset of CD4\n                    <jats:sup>+<\/jats:sup>\n                    T helper cells that secrete the cytokine IL-17 and play a role in autoimmunity. ROR\u03b3t is identified as a key transcription factor driving the T\n                    <jats:sub>H<\/jats:sub>\n                    17 differentiation. Sequence analysis indicated that transcription factor contains several conserved DNA-binding domain and isotype-specific domain that we termed transcription modulation domain (TMD). We designed a novel therapeutics, tROR\u03b3t-TMD, to deliver ROR\u03b3t-TMD efficiently into the nucleus of the cells that regulates T\n                    <jats:sub>H<\/jats:sub>\n                    17 cell functions and T\n                    <jats:sub>H<\/jats:sub>\n                    17-mediated autoimmune diseases. With the same concept, tTbet-TMD also can regulate T\n                    <jats:sub>H<\/jats:sub>\n                    1 functions. In conclusion, tROR\u03b3t-TMD\/tTbet-TMD can be novel and highly specific therapeutics for the treatment of T\n                    <jats:sub>H<\/jats:sub>\n                    17\/T\n                    <jats:sub>H<\/jats:sub>\n                    1-mediated inflammatory disease and further allows us to discover new function of ROR\u03b3t\/Tbet in animals without genetic alteration.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1413687112","type":"journal-article","created":{"date-parts":[[2014,12,19]],"date-time":"2014-12-19T23:13:50Z","timestamp":1419030830000},"page":"18673-18678","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["ROR\u03b3t-specific transcriptional interactomic inhibition suppresses autoimmunity associated with T\n                    <sub>H<\/sub>\n                    17 cells"],"prefix":"10.1073","volume":"111","author":[{"given":"Tae-Yoon","family":"Park","sequence":"first","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Dong","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Young","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Seung","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, College of Life Science and Biotechnology, Translational Research Center for Protein Function Control, Yonsei University, Seoul 120-749, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungsoo","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rho Hyun","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 151-742, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Won","family":"Lee","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Institute for Immunology and Immunological Disease, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Morio","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Developmental Biology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo 113-8519, Japan; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred L. 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