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U.S.A."],"published-print":{"date-parts":[[2015,3,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Voltage-gated sodium channels (Na\n                    <jats:sub>V<\/jats:sub>\n                    ) are known to form clusters at the membranes of excitable cells; however, what governs their transport is largely unknown. We found that the endoplasmic reticulum (ER) and\n                    <jats:italic>cis<\/jats:italic>\n                    -Golgi associated ubiquitin ligase really interesting new gene (RING) finger protein 121 (RNF121) mediates the degradation and membrane localization of Na\n                    <jats:sub>V<\/jats:sub>\n                    . This apparent quality control of Na\n                    <jats:sub>V<\/jats:sub>\n                    ensures the transport of properly folded channels to the membranes of excitable cells. 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