{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:20:12Z","timestamp":1791346812551,"version":"4.3.1"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"50","license":[{"start":{"date-parts":[[2015,6,16]],"date-time":"2015-06-16T00:00:00Z","timestamp":1434412800000},"content-version":"vor","delay-in-days":197,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","doi-asserted-by":"publisher","award":["AI090662"],"award-info":[{"award-number":["AI090662"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)","doi-asserted-by":"publisher","award":["AI075517"],"award-info":[{"award-number":["AI075517"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute (HHMI)","doi-asserted-by":"publisher","award":["NA"],"award-info":[{"award-number":["NA"]}],"id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,12,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Useful antimalarial drugs must be rapidly acting, highly efficacious, and have low potential for developing resistance. (+)-SJ733 targets a\n                    <jats:italic>Plasmodium<\/jats:italic>\n                    cation-transporting ATPase, ATP4. (+)-SJ733 cleared parasites in vivo as quickly as artesunate by specifically inducing eryptosis\/senescence in infected, treated erythrocytes. Although in vitro selection of\n                    <jats:italic>pfatp4<\/jats:italic>\n                    mutants with (+)-SJ733 proceeded with moderate frequency, during in vivo selection of\n                    <jats:italic>pbatp4<\/jats:italic>\n                    mutants, resistance emerged slowly and produced marginally resistant mutants with poor fitness. In addition, (+)-SJ733 met all other criteria for a clinical candidate, including high oral bioavailability, a high safety margin, and transmission blocking activity. These results demonstrate that targeting ATP4 has great potential to deliver useful drugs for malaria eradication.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1414221111","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T23:32:27Z","timestamp":1417476747000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":227,"title":["(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of\n                    <i>Plasmodium<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Mar\u00eda Bel\u00e9n","family":"Jim\u00e9nez-D\u00edaz","sequence":"first","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ebert","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2330;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandira","family":"Salinas","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anupam","family":"Pradhan","sequence":"additional","affiliation":[{"name":"Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adele M.","family":"Lehane","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University, Canberra, ACT, Australia 2601;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Eve","family":"Myrand-Lapierre","sequence":"additional","affiliation":[{"name":"Departments of Mechanical Engineering and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z4;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen G.","family":"O\u2019Loughlin","sequence":"additional","affiliation":[{"name":"Toxicology and Pharmacokinetics, SRI International, Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Shackleford","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia 3052;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Justino de Almeida","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela K.","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelaide S. M.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University, Canberra, ACT, Australia 2601;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon","family":"Diep","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2330;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Deng","sequence":"additional","affiliation":[{"name":"Departments of Mechanical Engineering and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z4;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Duffy","sequence":"additional","affiliation":[{"name":"Eskitis Institute, Brisbane Innovation Park, Nathan Campus, Griffith University, QLD, Australia 4111;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron N.","family":"Endsley","sequence":"additional","affiliation":[{"name":"Toxicology and Pharmacokinetics, SRI International, Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Fedewa","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2330;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. Armand","family":"Guiguemde","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda G.","family":"G\u00f3mez","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Holbrook","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Horst","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2330;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles C.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Experimental Medicine, University of California, San Francisco, CA 94110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus C. S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Matheny","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Santos","family":"Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ane","family":"Rodr\u00edguez-Alejandre","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sanz","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Sigal","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalie J.","family":"Spillman","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University, Canberra, ACT, Australia 2601;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip D.","family":"Stein","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Waterson","sequence":"additional","affiliation":[{"name":"Medicines for Malaria Venture, International Center Cointrin, 1215 Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer","family":"Knapp","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anang","family":"Shelat","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky M.","family":"Avery","sequence":"additional","affiliation":[{"name":"Eskitis Institute, Brisbane Innovation Park, Nathan Campus, Griffith University, QLD, Australia 4111;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Fidock","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology and Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco-Javier","family":"Gamo","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan A.","family":"Charman","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia 3052;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon C.","family":"Mirsalis","sequence":"additional","affiliation":[{"name":"Toxicology and Pharmacokinetics, SRI International, Menlo Park, CA 94025;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongshen","family":"Ma","sequence":"additional","affiliation":[{"name":"Departments of Mechanical Engineering and Urologic Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z4;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Ferrer","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiaran","family":"Kirk","sequence":"additional","affiliation":[{"name":"Research School of Biology, Australian National University, Canberra, ACT, Australia 2601;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I\u00f1igo","family":"Angulo-Barturen","sequence":"additional","affiliation":[{"name":"Tres Cantos Medicines Development Campus\u2013Diseases of the Developing World, GlaxoSmithKline, Tres Cantos 28760, Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis E.","family":"Kyle","sequence":"additional","affiliation":[{"name":"Department of Global Health, College of Public Health, University of South Florida, Tampa, FL 33612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"DeRisi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94158-2330;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Floyd","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, Piscataway, NJ 08854; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Kiplin","family":"Guy","sequence":"additional","affiliation":[{"name":"Department of Chemical Biology and Therapeutics, St. Jude Children\u2019s Research Hospital, Memphis, TN 38105;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_3_4_1_2","volume-title":"World Malaria Report","author":"World Health Organization","year":"2012","unstructured":"; World Health Organization World Malaria Report (WHO, Geneva, 2012)."},{"key":"e_1_3_4_2_2","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/1475-2875-11-316","article-title":"The global pipeline of new medicines for the control and elimination of malaria","volume":"11","author":"Anthony MP","year":"2012","unstructured":"MP Anthony, JN Burrows, S Duparc, JJ Moehrle, TN Wells, The global pipeline of new medicines for the control and elimination of malaria. Malar J 11, 316 (2012).","journal-title":"Malar J"},{"key":"e_1_3_4_3_2","doi-asserted-by":"crossref","first-page":"e62906","DOI":"10.1371\/journal.pone.0062906","article-title":"The open access malaria box: A drug discovery catalyst for neglected diseases","volume":"8","author":"Spangenberg T","year":"2013","unstructured":"T Spangenberg, , The open access malaria box: A drug discovery catalyst for neglected diseases. PLoS ONE 8, e62906 (2013).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_4_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/1475-2875-12-187","article-title":"Designing the next generation of medicines for malaria control and eradication","volume":"12","author":"Burrows JN","year":"2013","unstructured":"JN Burrows, RH van Huijsduijnen, JJ M\u00f6hrle, C Oeuvray, TN Wells, Designing the next generation of medicines for malaria control and eradication. Malar J 12, 187 (2013).","journal-title":"Malar J"},{"key":"e_1_3_4_5_2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.2174\/156802612799362977","article-title":"Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials","volume":"12","author":"Chatterjee AK","year":"2012","unstructured":"AK Chatterjee, BK Yeung, Back to the future: Lessons learned in modern target-based and whole-cell lead optimization of antimalarials. Curr Top Med Chem 12, 473\u2013483 (2012).","journal-title":"Curr Top Med Chem"},{"key":"e_1_3_4_6_2","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/ng.2648","article-title":"Genome sequencing sheds light on emerging drug resistance in malaria parasites","volume":"45","author":"Neafsey DE","year":"2013","unstructured":"DE Neafsey, Genome sequencing sheds light on emerging drug resistance in malaria parasites. Nat Genet 45, 589\u2013590 (2013).","journal-title":"Nat Genet"},{"key":"e_1_3_4_7_2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/nature09099","article-title":"Chemical genetics of Plasmodium falciparum","volume":"465","author":"Guiguemde WA","year":"2010","unstructured":"WA Guiguemde, , Chemical genetics of Plasmodium falciparum. Nature 465, 311\u2013315 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_8_2","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1126\/science.1193225","article-title":"Spiroindolones, a potent compound class for the treatment of malaria","volume":"329","author":"Rottmann M","year":"2010","unstructured":"M Rottmann, , Spiroindolones, a potent compound class for the treatment of malaria. Science 329, 1175\u20131180 (2010).","journal-title":"Science"},{"key":"e_1_3_4_9_2","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1128\/AAC.00519-09","article-title":"Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes","volume":"53","author":"Jim\u00e9nez-D\u00edaz MB","year":"2009","unstructured":"MB Jim\u00e9nez-D\u00edaz, , Improved murine model of malaria using Plasmodium falciparum competent strains and non-myelodepleted NOD-scid IL2Rgammanull mice engrafted with human erythrocytes. Antimicrob Agents Chemother 53, 4533\u20134536 (2009).","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_4_10_2","doi-asserted-by":"crossref","first-page":"13052","DOI":"10.1073\/pnas.1210585109","article-title":"Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite","volume":"109","author":"Park DJ","year":"2012","unstructured":"DJ Park, , Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite. Proc Natl Acad Sci USA 109, 13052\u201313057 (2012).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_11_2","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2105-10-80","article-title":"CNV-seq, a new method to detect copy number variation using high-throughput sequencing","volume":"10","author":"Xie C","year":"2009","unstructured":"C Xie, MT Tammi, CNV-seq, a new method to detect copy number variation using high-throughput sequencing. BMC Bioinformatics 10, 80 (2009).","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_4_12_2","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.chom.2012.12.006","article-title":"Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials","volume":"13","author":"Spillman NJ","year":"2013","unstructured":"NJ Spillman, , Na+ regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe 13, 227\u2013237 (2013).","journal-title":"Cell Host Microbe"},{"key":"e_1_3_4_13_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.molbiopara.2013.04.004","article-title":"Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite","volume":"189","author":"Spillman NJ","year":"2013","unstructured":"NJ Spillman, RJ Allen, K Kirk, Na+ extrusion imposes an acid load on the intraerythrocytic malaria parasite. Mol Biochem Parasitol 189, 1\u20134 (2013).","journal-title":"Mol Biochem Parasitol"},{"key":"e_1_3_4_14_2","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1128\/AAC.36.4.704","article-title":"Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum","volume":"36","author":"Rathod PK","year":"1992","unstructured":"PK Rathod, NP Leffers, RD Young, Molecular targets of 5-fluoroorotate in the human malaria parasite, Plasmodium falciparum. Antimicrob Agents Chemother 36, 704\u2013711 (1992).","journal-title":"Antimicrob Agents Chemother"},{"key":"e_1_3_4_15_2","first-page":"387","article-title":"Mechanisms tagging senescent red blood cells for clearance in healthy humans","volume":"4","author":"Lutz HU","year":"2013","unstructured":"HU Lutz, A Bogdanova, Mechanisms tagging senescent red blood cells for clearance in healthy humans. Front Physiol 4, 387 (2013).","journal-title":"Front Physiol"},{"key":"e_1_3_4_16_2","doi-asserted-by":"crossref","first-page":"5215","DOI":"10.1182\/blood-2010-10-313239","article-title":"Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver","volume":"117","author":"Lee SJ","year":"2011","unstructured":"SJ Lee, SY Park, MY Jung, SM Bae, IS Kim, Mechanism for phosphatidylserine-dependent erythrophagocytosis in mouse liver. Blood 117, 5215\u20135223 (2011).","journal-title":"Blood"},{"key":"e_1_3_4_17_2","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/ajh.23476","article-title":"Microfluidic analysis of cellular deformability of normal and oxidatively damaged red blood cells","volume":"88","author":"Kwan JM","year":"2013","unstructured":"JM Kwan, Q Guo, DL Kyluik-Price, H Ma, MD Scott, Microfluidic analysis of cellular deformability of normal and oxidatively damaged red blood cells. Am J Hematol 88, 682\u2013689 (2013).","journal-title":"Am J Hematol"},{"key":"e_1_3_4_18_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1111\/j.1749-6632.1989.tb22423.x","article-title":"Cell membrane and volume changes during red cell development and aging","volume":"554","author":"Mohandas N","year":"1989","unstructured":"N Mohandas, W Groner, Cell membrane and volume changes during red cell development and aging. Ann N Y Acad Sci 554, 217\u2013224 (1989).","journal-title":"Ann N Y Acad Sci"},{"key":"e_1_3_4_19_2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fphys.2014.00009","article-title":"Of macrophages and red blood cells: A complex love story","volume":"5","author":"de Back DZ","year":"2014","unstructured":"DZ de Back, EB Kostova, M van Kraaij, TK van den Berg, R van Bruggen, Of macrophages and red blood cells: A complex love story. Front Physiol 5, 9 (2014).","journal-title":"Front Physiol"},{"key":"e_1_3_4_20_2","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1172\/JCI111913","article-title":"Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes","volume":"75","author":"Schwartz RS","year":"1985","unstructured":"RS Schwartz, , Increased adherence of sickled and phosphatidylserine-enriched human erythrocytes to cultured human peripheral blood monocytes. J Clin Invest 75, 1965\u20131972 (1985).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_21_2","doi-asserted-by":"crossref","first-page":"5131","DOI":"10.1016\/S0021-9258(18)89189-X","article-title":"In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes","volume":"260","author":"Schroit AJ","year":"1985","unstructured":"AJ Schroit, JW Madsen, Y Tanaka, In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes. J Biol Chem 260, 5131\u20135138 (1985).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_22_2","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1182\/blood.V46.6.965.965","article-title":"Contrasting splenic mechanisms in the blood clearance of red blood cells and colloidal particles","volume":"46","author":"Klausner MA","year":"1975","unstructured":"MA Klausner, , Contrasting splenic mechanisms in the blood clearance of red blood cells and colloidal particles. Blood 46, 965\u2013976 (1975).","journal-title":"Blood"},{"key":"e_1_3_4_23_2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1159\/000233238","article-title":"Suicide for survival\u2014death of infected erythrocytes as a host mechanism to survive malaria","volume":"24","author":"F\u00f6ller M","year":"2009","unstructured":"M F\u00f6ller, , Suicide for survival\u2014death of infected erythrocytes as a host mechanism to survive malaria. Cell Physiol Biochem 24, 133\u2013140 (2009).","journal-title":"Cell Physiol Biochem"},{"key":"e_1_3_4_24_2","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1136\/jcp.2006.037523","article-title":"Assessment of erythrocyte shape by flow cytometry techniques","volume":"60","author":"Piagnerelli M","year":"2007","unstructured":"M Piagnerelli, , Assessment of erythrocyte shape by flow cytometry techniques. J Clin Pathol 60, 549\u2013554 (2007).","journal-title":"J Clin Pathol"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"e59862","DOI":"10.1371\/journal.pone.0059862","article-title":"Flow cytometric assessment of erythrocyte shape through analysis of FSC histograms: Use of kurtosis and implications for longitudinal evaluation","volume":"8","author":"Ahlgrim C","year":"2013","unstructured":"C Ahlgrim, T Pottgiesser, T Sander, YO Schumacher, MW Baumstark, Flow cytometric assessment of erythrocyte shape through analysis of FSC histograms: Use of kurtosis and implications for longitudinal evaluation. PLoS ONE 8, e59862 (2013).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1039\/c2lc20857a","article-title":"Microfluidic biomechanical assay for red blood cells parasitized by Plasmodium falciparum","volume":"12","author":"Guo Q","year":"2012","unstructured":"Q Guo, SJ Reiling, P Rohrbach, H Ma, Microfluidic biomechanical assay for red blood cells parasitized by Plasmodium falciparum. Lab Chip 12, 1143\u20131150 (2012).","journal-title":"Lab Chip"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1083\/jcb.98.4.1201","article-title":"Adhesivity and rigidity of erythrocyte membrane in relation to wheat germ agglutinin binding","volume":"98","author":"Evans E","year":"1984","unstructured":"E Evans, A Leung, Adhesivity and rigidity of erythrocyte membrane in relation to wheat germ agglutinin binding. J Cell Biol 98, 1201\u20131208 (1984).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/0011-2240(80)90067-X","article-title":"The relationship between cell injury and osmotic volume reduction: II. Red cell lysis correlates with cell volume rather than intracellular salt concentration","volume":"17","author":"Williams RJ","year":"1980","unstructured":"RJ Williams, SK Shaw, The relationship between cell injury and osmotic volume reduction: II. Red cell lysis correlates with cell volume rather than intracellular salt concentration. Cryobiology 17, 530\u2013539 (1980).","journal-title":"Cryobiology"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"157","DOI":"10.4269\/ajtmh.1988.39.157","article-title":"X-ray microanalysis of Plasmodium falciparum and infected red blood cells: Effects of qinghaosu and chloroquine on potassium, sodium, and phosphorus composition","volume":"39","author":"Lee P","year":"1988","unstructured":"P Lee, Z Ye, K Van Dyke, RG Kirk, X-ray microanalysis of Plasmodium falciparum and infected red blood cells: Effects of qinghaosu and chloroquine on potassium, sodium, and phosphorus composition. Am J Trop Med Hyg 39, 157\u2013165 (1988).","journal-title":"Am J Trop Med Hyg"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1056\/NEJMoa1315860","article-title":"Spiroindolone KAE609 for falciparum and vivax malaria","volume":"371","author":"White NJ","year":"2014","unstructured":"NJ White, , Spiroindolone KAE609 for falciparum and vivax malaria. N Engl J Med 371, 403\u2013410 (2014).","journal-title":"N Engl J Med"}],"updated-by":[{"DOI":"10.1073\/pnas.1518632112","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000}}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1414221111","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1414221111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T07:57:29Z","timestamp":1654588649000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1414221111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":30,"journal-issue":{"issue":"50","published-print":{"date-parts":[[2014,12,16]]}},"alternative-id":["10.1073\/pnas.1414221111"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1414221111","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"2014-12-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}