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In Ctr mice, sildenafil did not reduce the AII-induced increase of cardiomyocyte (CM) size or myocyte hypertrophic markers but did reduce fibrosis. In \u03b2RM mice, sildenafil had little or no effect on markers of fibrosis. These results show that the sildenafil\/cGMP\/cGKI cascade can have an inhibitory effect on cardiac fibrosis but not on CM hypertrophy.<\/jats:p>","DOI":"10.1073\/pnas.1414364111","type":"journal-article","created":{"date-parts":[[2014,8,19]],"date-time":"2014-08-19T23:39:11Z","timestamp":1408491551000},"page":"12925-12929","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":69,"title":["Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis"],"prefix":"10.1073","volume":"111","author":[{"given":"Enrico","family":"Patrucco","sequence":"first","affiliation":[{"name":"Forschergruppe 923, Institut f\u00fcr Pharmakologie und Toxikologie, Technische Universit\u00e4t M\u00fcnchen, 80802 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Domes","sequence":"additional","affiliation":[{"name":"Forschergruppe 923, Institut f\u00fcr Pharmakologie und Toxikologie, Technische Universit\u00e4t M\u00fcnchen, 80802 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Sbroggi\u00f3","sequence":"additional","affiliation":[{"name":"Centro Nacional de Investigaciones Cardiovasculares, E-28029 Madrid, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Blaich","sequence":"additional","affiliation":[{"name":"Forschergruppe 923, Institut f\u00fcr Pharmakologie und Toxikologie, Technische Universit\u00e4t M\u00fcnchen, 80802 Munich, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Schlossmann","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Pharmakologie und Toxikologie, Institut f\u00fcr Pharmazie, Universit\u00e4t Regensburg, 93055 Regensburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Desch","sequence":"additional","affiliation":[{"name":"Lehrstuhl f\u00fcr Pharmakologie und Toxikologie, Institut f\u00fcr Pharmazie, Universit\u00e4t Regensburg, 93055 Regensburg, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergei D.","family":"Rybalkin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Washington, Seattle, WA 98195-7280; 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