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In addition, we found that influenza viral-promoted bacterial adherence was dependent on bacterial fibronectin-binding protein. The results indicate that up-regulated expression of cellular adhesins by TGF-\u03b2, which is activated in influenza viral infection, increases host susceptibility to bacterial coinfection and suggest that TGF-\u03b2 and host adhesion molecules are potential pharmaceutical targets for prevention of coinfection.<\/jats:p>","DOI":"10.1073\/pnas.1414422112","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T22:44:11Z","timestamp":1419288251000},"page":"238-243","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":139,"title":["Influenza viral neuraminidase primes bacterial coinfection through TGF-\u03b2\u2013mediated expression of host cell receptors"],"prefix":"10.1073","volume":"112","author":[{"given":"Ning","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aihui","family":"Ren","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George F.","family":"Gao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Cleary","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Minnesota, Minneapolis, MN 55455"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9260-7197","authenticated-orcid":false,"given":"Beinan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1086\/591708"},{"key":"e_1_3_3_2_2","first-page":"1071","article-title":"Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1) - United States, May-August 2009","volume":"58","author":"Anonymous","year":"2009","unstructured":"Anonymous, Bacterial coinfections in lung tissue specimens from fatal cases of 2009 pandemic influenza A (H1N1) - United States, May-August 2009. 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