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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,12,16]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Erythritol is a preferential substrate for\n                    <jats:italic>Brucella<\/jats:italic>\n                    , a common zoonotic bacterial pathogen. This four-carbon polyol is found in the reproductive organs of several affected species, a feature that may account for the characteristic viscerotropism of\n                    <jats:italic>Brucella<\/jats:italic>\n                    that leads to sterility and abortion. Although described previously as feeding glycolysis via dihydroxyacetone-phosphate, we show here that erythritol is actually converted into D-erythrose-4-phosphate through a hitherto undescribed set of reactions that involves three isomerases and that allows hexose-monophosphate synthesis and growth by feeding the pentose phosphate shunt. Elucidation of this unique carbohydrate pathway, which also applies to the\n                    <jats:italic>Rhizobiales<\/jats:italic>\n                    plant endosymbionts, opens the way for further research on the metabolic adaptation of an important facultative intracellular pathogen to target organs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1414622111","type":"journal-article","created":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T23:32:27Z","timestamp":1417476747000},"page":"17815-17820","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":68,"title":["Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in\n                    <i>Brucella<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Thibault","family":"Barbier","sequence":"first","affiliation":[{"name":"Research Unit in Microorganisms Biology, University of Namur, B-5000 Namur, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Collard","sequence":"additional","affiliation":[{"name":"Welbio and de Duve Institute, Universit\u00e9 Catholique de Louvain, B-1200 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaia","family":"Z\u00fa\u00f1iga-Ripa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Instituto de Salud Tropical, Universidad de Navarra, 31008 Pamplona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Moriy\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda e Instituto de Salud Tropical, Universidad de Navarra, 31008 Pamplona, Spain;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Godard","sequence":"additional","affiliation":[{"name":"Institute of Biochemical Engineering, Technische Universit\u00e4t Braunschweig, 38106 Braunschweig, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Becker","sequence":"additional","affiliation":[{"name":"Institute of Systems Biotechnology, Saarland University, 66123 Saarbr\u00fccken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Institute of Systems Biotechnology, Saarland University, 66123 Saarbr\u00fccken, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emile","family":"Van Schaftingen","sequence":"additional","affiliation":[{"name":"Welbio and de Duve Institute, Universit\u00e9 Catholique de Louvain, B-1200 Brussels, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Letesson","sequence":"additional","affiliation":[{"name":"Research Unit in Microorganisms Biology, University of Namur, B-5000 Namur, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,12]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-micro-090110-102905"},{"key":"e_1_3_3_2_2","first-page":"47","article-title":"Three aspects of bovine brucellosis: Epidemiology, the role of bulls and vaccines","volume":"19","author":"Corner LA","year":"1983","unstructured":"LA Corner, Three aspects of bovine brucellosis: Epidemiology, the role of bulls and vaccines. 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