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This low-cost, simple test could provide a means to enable diagnosis of sickle cell disease in low-resource settings and enable life-saving interventions for children with the disease. The method itself provides a demonstration of the use of a biophysical indicator (here, density) rather than a biochemical marker (e.g., proteins separated by gel electrophoresis) as a means to do point-of-care hematology.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1414739111","type":"journal-article","created":{"date-parts":[[2014,9,2]],"date-time":"2014-09-02T23:56:19Z","timestamp":1409702179000},"page":"14864-14869","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["Density-based separation in multiphase systems provides a simple method to identify sickle cell disease"],"prefix":"10.1073","volume":"111","author":[{"given":"Ashok A.","family":"Kumar","sequence":"first","affiliation":[{"name":"School of Engineering and Applied Sciences,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew R.","family":"Patton","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Hennek","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si Yi Ryan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetana","family":"D\u2019Alesio-Spina","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Chemical Biology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering, Tulane University, New Orleans, LA 70118;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Kanter","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425; 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