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U.S.A."],"published-print":{"date-parts":[[2015,1,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Polycystic ovarian syndrome (PCOS) is the leading cause of anovulatory infertility. Although the etiology of PCOS is unclear, disrupted central mechanisms mediating steroid hormone feedback to gonadotropin-releasing hormone (GnRH) neurons have been suggested. We describe here, in a mouse model reflecting the clinical neuroendocrine phenotype of PCOS, evidence for disordered progesterone (P4)-sensitive GABAergic input to GnRH neurons, originating specifically within the arcuate nucleus. These discoveries define a previously unidentified neuronal pathway, potentially critical for the steroid hormone feedback control of fertility. 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