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U.S.A."],"published-print":{"date-parts":[[2015,1,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>We demonstrate that histone deacetylase (HDAC) inhibition can elicit changes in DNA methylation in Huntington\u2019s disease (HD) human fibroblasts, as well as in sperm from HD transgenic mice, in association with DNA methylation-related gene expression changes. We suggest that alterations in sperm DNA methylation lead to transgenerational effects, and, accordingly, we show that first filial generation (F1) offspring of HDAC inhibitor-treated male HD transgenic mice show improved HD disease phenotypes compared with F1 offspring from vehicle-treated male HD transgenic mice. These findings have significant implications for human health because they enforce the concept that ancestral drug exposure may be a major molecular factor that can affect disease phenotypes, yet in a positive manner. Further, we implicate Lys (K)-specific demethylase 5d expression in this phenomenon.<\/jats:p>","DOI":"10.1073\/pnas.1415195112","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T22:44:11Z","timestamp":1419288251000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":94,"title":["HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation"],"prefix":"10.1073","volume":"112","author":[{"given":"Haiqun","family":"Jia","sequence":"first","affiliation":[{"name":"Departments of aMolecular and Cellular Neuroscience and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles D.","family":"Morris","sequence":"additional","affiliation":[{"name":"Departments of aMolecular and Cellular Neuroscience and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy M.","family":"Williams","sequence":"additional","affiliation":[{"name":"Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanne F.","family":"Loring","sequence":"additional","affiliation":[{"name":"Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth A.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Departments of aMolecular and Cellular Neuroscience and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,12,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4161\/nucl.21481","article-title":"Polyglutamine (polyQ) disorders: The chromatin connection","volume":"3","author":"Cohen-Carmon D","year":"2012","unstructured":"D Cohen-Carmon, E Meshorer, Polyglutamine (polyQ) disorders: The chromatin connection. 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Cell 127, 59\u201369 (2006).","journal-title":"Cell"},{"key":"e_1_3_4_29_2","doi-asserted-by":"crossref","first-page":"e135","DOI":"10.1371\/journal.pgen.0030135","article-title":"Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism","volume":"3","author":"Lee JM","year":"2007","unstructured":"JM Lee, , Unbiased gene expression analysis implicates the huntingtin polyglutamine tract in extra-mitochondrial energy metabolism. PLoS Genet 3, e135 (2007).","journal-title":"PLoS Genet"},{"key":"e_1_3_4_30_2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nature10572","article-title":"Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans","volume":"479","author":"Greer EL","year":"2011","unstructured":"EL Greer, , Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans. 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Curr Genomics 9, 500\u2013508 (2008).","journal-title":"Curr Genomics"},{"key":"e_1_3_4_33_2","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/14647273.2010.524721","article-title":"Male-line transgenerational responses in humans","volume":"13","author":"Pembrey ME","year":"2010","unstructured":"ME Pembrey, Male-line transgenerational responses in humans. Hum Fertil (Camb) 13, 268\u2013271 (2010).","journal-title":"Hum Fertil (Camb)"},{"key":"e_1_3_4_34_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.ejhg.5201538","article-title":"Sex-specific, male-line transgenerational responses in humans","volume":"14","author":"Pembrey ME","year":"2006","unstructured":"ME Pembrey, , Sex-specific, male-line transgenerational responses in humans. Eur J Hum Genet; ALSPAC Study Team 14, 159\u2013166 (2006).","journal-title":"Eur J Hum Genet"},{"key":"e_1_3_4_35_2","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.cell.2010.12.008","article-title":"Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals","volume":"143","author":"Carone BR","year":"2010","unstructured":"BR Carone, , Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals. Cell 143, 1084\u20131096 (2010).","journal-title":"Cell"},{"key":"e_1_3_4_36_2","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/nature09491","article-title":"Chronic high-fat diet in fathers programs \u03b2-cell dysfunction in female rat offspring","volume":"467","author":"Ng SF","year":"2010","unstructured":"SF Ng, , Chronic high-fat diet in fathers programs \u03b2-cell dysfunction in female rat offspring. Nature 467, 963\u2013966 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_37_2","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nature06714","article-title":"Chromatin dynamics during epigenetic reprogramming in the mouse germ line","volume":"452","author":"Hajkova P","year":"2008","unstructured":"P Hajkova, , Chromatin dynamics during epigenetic reprogramming in the mouse germ line. Nature 452, 877\u2013881 (2008).","journal-title":"Nature"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0960-9822(00)00448-6","article-title":"Active demethylation of the paternal genome in the mouse zygote","volume":"10","author":"Oswald J","year":"2000","unstructured":"J Oswald, , Active demethylation of the paternal genome in the mouse zygote. 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In Vitro Cell Dev Biol Anim 50, 603\u2013613 (2014).","journal-title":"In Vitro Cell Dev Biol Anim"},{"key":"e_1_3_4_41_2","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.celrep.2014.02.044","article-title":"A histone methylation network regulates transgenerational epigenetic memory in C. elegans","volume":"7","author":"Greer EL","year":"2014","unstructured":"EL Greer, , A histone methylation network regulates transgenerational epigenetic memory in C. elegans. 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Obes Rev 8, 487\u2013502 (2007).","journal-title":"Obes Rev"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.tem.2009.12.007","article-title":"Epigenetic transgenerational actions of environmental factors in disease etiology","volume":"21","author":"Skinner MK","year":"2010","unstructured":"MK Skinner, M Manikkam, C Guerrero-Bosagna, Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab 21, 214\u2013222 (2010).","journal-title":"Trends Endocrinol Metab"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"e44498","DOI":"10.1371\/journal.pone.0044498","article-title":"Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo","volume":"7","author":"Beconi M","year":"2012","unstructured":"M Beconi, , Oral administration of the pimelic diphenylamide HDAC inhibitor HDACi 4b is unsuitable for chronic inhibition of HDAC activity in the CNS in vivo. PLoS ONE 7, e44498 (2012).","journal-title":"PLoS ONE"},{"key":"e_1_3_4_45_2","first-page":"5","article-title":"Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6\/2 and N171-82Q Mouse Models of Huntington\u2019s Disease","volume":"5","author":"Chen JY","year":"2013","unstructured":"JY Chen, , Effects of the Pimelic Diphenylamide Histone Deacetylase Inhibitor HDACi 4b on the R6\/2 and N171-82Q Mouse Models of Huntington\u2019s Disease. PLoS Curr 5, 5 (2013).","journal-title":"PLoS Curr"},{"key":"e_1_3_4_46_2","volume-title":"Guide for the Care and Use of Laboratory Animals","author":"Committee on Care and Use of Laboratory Animals","year":"1996","unstructured":"; Committee on Care and Use of Laboratory Animals Guide for the Care and Use of Laboratory Animals (Natl Inst Health, Bethesda, DHHS Publ No (NIH) 85-23. 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