{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:07:10Z","timestamp":1791407230540,"version":"4.3.3"},"reference-count":33,"publisher":"National Academy of Sciences","issue":"39","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2014,9,30]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Inherited mutations in the tumor suppressor genes\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    predispose to very high risks of breast and ovarian cancer. For carriers of these mutations, risk-reducing surgery significantly reduces morbidity and mortality. General population screening for\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutations in young adult women could be feasible if accurate estimates of cancer risk for mutation carriers could be obtained. We determined that risks of breast and ovarian cancer for\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    mutation carriers ascertained from the general population are as high as for mutation carriers ascertained through personal or family history of cancer. General screening of\n                    <jats:italic>BRCA1<\/jats:italic>\n                    and\n                    <jats:italic>BRCA2<\/jats:italic>\n                    would identify many carriers who are currently not evaluated and could serve as a model for population screening for genetic predisposition to cancer.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1415979111","type":"journal-article","created":{"date-parts":[[2014,9,6]],"date-time":"2014-09-06T03:25:27Z","timestamp":1409973927000},"page":"14205-14210","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":302,"title":["Population-based screening for breast and ovarian cancer risk due to\n                    <i>BRCA1<\/i>\n                    and\n                    <i>BRCA2<\/i>"],"prefix":"10.1073","volume":"111","author":[{"given":"Efrat","family":"Gabai-Kapara","sequence":"first","affiliation":[{"name":"Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel;"},{"name":"Faculty of Medicine, Hebrew University Medical School, Jerusalem 91120, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amnon","family":"Lahad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University Medical School, Jerusalem 91120, Israel;"},{"name":"Department of Family Medicine, Clalit Health Services, Jerusalem 91120, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bella","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Institute of Oncology, Sheba Medical Center, Tel Hashomer 52621, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eitan","family":"Friedman","sequence":"additional","affiliation":[{"name":"Susanne Levy Gertner Oncogenetics Unit, Sheba Medical Center, Tel Hashomer 52621, Israel;"},{"name":"Sackler School of Medicine, Tel Aviv University, Tel-Aviv 69978, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomo","family":"Segev","sequence":"additional","affiliation":[{"name":"Institute of Medical Screening, Sheba Medical Center, Tel Hashomer 52621, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Renbaum","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Beeri","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moran","family":"Gal","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Grinshpun-Cohen","sequence":"additional","affiliation":[{"name":"Medical Genetics Institute, Shaare Zedek Medical Center, Jerusalem 91031, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Djemal","sequence":"additional","affiliation":[{"name":"Terem Family Medical Center, Jerusalem 92345, Israel;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica B.","family":"Mandell","sequence":"additional","affiliation":[{"name":"Departments of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195; 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