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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,1,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Infant trauma induces preference learning about trauma-linked cues but negatively programs neurobehavioral development. Despite clinical evidence that trauma-linked cues remain powerful throughout life, the mechanisms underlying the interaction between infant trauma cues and the long-term effects of trauma are unknown. Using a rodent model of trauma bonding, which produces a life-long preferred odor and enduring effects that parallel the sequelae of child abuse, we show that the infant trauma odor rescues adult depressive-like behavior and amygdala dysfunction. Assessment of neural mechanism implicates amygdala serotonin (5-HT) and glucocorticoids (GCs). Our findings suggest that trauma-linked cues have an unexpected positive value in adulthood (i.e., antidepressant properties) and may provide insight as to why victims of childhood abuse are attracted to abuse-related cues.<\/jats:p>","DOI":"10.1073\/pnas.1416065112","type":"journal-article","created":{"date-parts":[[2015,1,5]],"date-time":"2015-01-05T23:08:12Z","timestamp":1420499292000},"page":"881-886","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":46,"title":["Enduring good memories of infant trauma: Rescue of adult neurobehavioral deficits via amygdala serotonin and corticosterone interaction"],"prefix":"10.1073","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2689-915X","authenticated-orcid":false,"given":"Millie","family":"Rinc\u00f3n-Cort\u00e9s","sequence":"first","affiliation":[{"name":"Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962;"},{"name":"Neuroscience and Physiology, Sackler Institute, New York University School of Medicine, New York, NY 10016;"},{"name":"Child and Adolescent Psychiatry, The Child Study Center, New York University Langone Medical Center, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A.","family":"Barr","sequence":"additional","affiliation":[{"name":"Anesthesia and Critical Care Medicine, Children\u2019s Hospital of Philadelphia, Philadelphia, PA 19104;"},{"name":"Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Mouly","sequence":"additional","affiliation":[{"name":"Lyon Neuroscience Research Center, INSERM U1028, CNRS UMR5292, University Lyon1, F-69366 Lyon, France; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiseko","family":"Shionoya","sequence":"additional","affiliation":[{"name":"Division of Cell Biology, Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping 58183, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bestina S.","family":"Nu\u00f1ez","sequence":"additional","affiliation":[{"name":"Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina M.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962;"},{"name":"Neuroscience and Physiology, Sackler Institute, New York University School of Medicine, New York, NY 10016;"},{"name":"Child and Adolescent Psychiatry, The Child Study Center, New York University Langone Medical Center, NY 10016;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,1,5]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0193-953X(01)00003-X","article-title":"Developmental neurobiology of childhood stress and trauma","volume":"25","author":"Teicher MH","year":"2002","unstructured":"MH Teicher, SL Andersen, A Polcari, CM Anderson, CP Navalta, Developmental neurobiology of childhood stress and trauma. 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