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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,1,13]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (MTB) infection is one of the most common diseases worldwide. The\n                    <jats:italic>Mycobacteria<\/jats:italic>\n                    are a large bacterial family that includes MTB and nontuberculous mycobacteria commonly found in the environment (NTMs). We have shown that non\u2013MTB-infected and non\u2013bacillus Calmette\u2013Guerin-vaccinated individuals nevertheless react to MTB-derived sequences. This reactivity can be explained by conservation of the epitope sequence in NTMs. Thus, the widespread exposure to various species of\n                    <jats:italic>Mycobacteria<\/jats:italic>\n                    influences reactivity to MTB and NTMs. We identified epitopes that are found only in NTMs, allowing dissociation of MTB- versus NTM-specific reactivity. These epitopes, in conjunction with epitopes specific to latent MTB infection, will provide a novel tool to study host\u2013pathogen dynamics in the context of the design and evaluation of MTB vaccines and diagnostics.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1416537112","type":"journal-article","created":{"date-parts":[[2014,12,30]],"date-time":"2014-12-30T05:04:50Z","timestamp":1419915890000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":66,"title":["Immunological consequences of intragenus conservation of\n                    <i>Mycobacterium tuberculosis<\/i>\n                    T-cell epitopes"],"prefix":"10.1073","volume":"112","author":[{"given":"Cecilia S.","family":"Lindestam Arlehamn","sequence":"first","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinu","family":"Paul","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Mele","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera Italiana, 6500 Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlie","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason A.","family":"Greenbaum","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randi","family":"Vita","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Sidney","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjoern","family":"Peters","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Sallusto","sequence":"additional","affiliation":[{"name":"Institute for Research in Biomedicine, Universit\u00e0 della Svizzera Italiana, 6500 Bellinzona, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Sette","sequence":"additional","affiliation":[{"name":"Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,12,29]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1378\/chest.07-0358","article-title":"Pulmonary disease due to nontuberculous mycobacteria","volume":"133","author":"Glassroth J","year":"2008","unstructured":"J Glassroth, Pulmonary disease due to nontuberculous mycobacteria. 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