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These findings underscore the existence of a link between the ribosomal tunnel and the peptidyl transferase center and pave the way for development of superior antibiotics.<\/jats:p>","DOI":"10.1073\/pnas.1417334111","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T03:24:15Z","timestamp":1414466655000},"page":"15958-15963","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":183,"title":["The general mode of translation inhibition by macrolide antibiotics"],"prefix":"10.1073","volume":"111","author":[{"given":"Krishna","family":"Kannan","sequence":"first","affiliation":[{"name":"Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pinal","family":"Kanabar","sequence":"additional","affiliation":[{"name":"Center for Research Informatics (CRI), Research Resources Center, University of Illinois, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Schryer","sequence":"additional","affiliation":[{"name":"Institute of Technology, University of Tartu, 50411 Tartu, Estonia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Florin","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607;"},{"name":"Institute of Biochemistry and Biology, University of Potsdam, D-14424 Potsdam, Germany; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Oh","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute,"},{"name":"Department of Cellular and Molecular Pharmacology, and"},{"name":"California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Bahroos","sequence":"additional","affiliation":[{"name":"Center for Research Informatics (CRI), Research Resources Center, University of Illinois, Chicago, IL 60612;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanel","family":"Tenson","sequence":"additional","affiliation":[{"name":"Institute of Technology, University of Tartu, 50411 Tartu, Estonia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan S.","family":"Weissman","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute,"},{"name":"Department of Cellular and Molecular Pharmacology, and"},{"name":"California Institute for Quantitative Biosciences, University of California, San Francisco, CA 94158"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Mankin","sequence":"additional","affiliation":[{"name":"Center for Pharmaceutical Biotechnology, University of Illinois, Chicago, IL 60607;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,10,27]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"17152","DOI":"10.1073\/pnas.1007988107","article-title":"Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action","volume":"107","author":"Dunkle JA","year":"2010","unstructured":"JA Dunkle, L Xiong, AS Mankin, JH Cate, Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action. 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