{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:31:31Z","timestamp":1791495091881,"version":"4.3.4"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"1","license":[{"start":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T00:00:00Z","timestamp":1419206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["AI89716"],"award-info":[{"award-number":["AI89716"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,1,6]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Varicella-zoster virus (VZV) is an important pathogen, which causes varicella and herpes zoster in humans. In general, there are similarities in virus-host interactions between the alphaherpesviruses. One notable exception is the response to autophagy. VZV infection induces autophagy. This is in contrast to herpes simplex virus (HSV), which has two genes that inhibit autophagy, ICP34.5 and US11; neither is present in the smaller VZV genome. In this study, we found that VZV-induced autophagic flux was not blocked. These results reinforce prior observations showing a proviral effect of autophagy on VZV infectivity and spread. These VZV findings also exhibit similarities with recent data about a requirement for early phase autophagy during Epstein\u2013Barr virus infection, a phylogenetically distant gammaherpesvirus.<\/jats:p>","DOI":"10.1073\/pnas.1417878112","type":"journal-article","created":{"date-parts":[[2014,12,22]],"date-time":"2014-12-22T22:44:11Z","timestamp":1419288251000},"page":"256-261","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":47,"title":["Autophagic flux without a block differentiates varicella-zoster virus infection from herpes simplex virus infection"],"prefix":"10.1073","volume":"112","author":[{"given":"Erin M.","family":"Buckingham","sequence":"first","affiliation":[{"name":"Virology Laboratory, Department of Pediatrics, University of Iowa Children\u2019s Hospital, Iowa City, IA 52242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Department of Pediatrics, University of Iowa Children\u2019s Hospital, Iowa City, IA 52242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallen","family":"Jackson","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Department of Pediatrics, University of Iowa Children\u2019s Hospital, Iowa City, IA 52242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leigh","family":"Zerboni","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Arvin","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Grose","sequence":"additional","affiliation":[{"name":"Virology Laboratory, Department of Pediatrics, University of Iowa Children\u2019s Hospital, Iowa City, IA 52242; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,12,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02646-13"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jviromet.2013.06.018"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.21.5720"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027485"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.2.965-974.1998"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.5.2651-2658.2005"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2014.00322"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2173860"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2006.12.001"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01356-07"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1720"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00267-12"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01158-12"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro3215"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02670-08"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00281-11"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00081-09"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02137-08"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.5475"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.080796"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.1889"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2010.03.002"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.28448"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.4451"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.1.1.1542"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.68.1.48-55.1994"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-67-9-1759"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-79-7-1613"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03500-12"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015396430131"},{"key":"e_1_3_3_31_2","first-page":"1","article-title":"The varicella-zoster virus genome","volume":"342","author":"Cohen JI","year":"2010","unstructured":"JI Cohen, The varicella-zoster virus genome. Curr Top Microbiol Immunol 342, 1\u201314 (2010).","journal-title":"Curr Top Microbiol Immunol"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00357-12"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040634"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1002157"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114232109"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.4161\/auto.19496"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature11866"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01849-13"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02199-14"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00715-06"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1128\/iai.19.1.199-203.1978"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.20.11969"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.6890-6899.2005"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1417878112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1417878112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:24:00Z","timestamp":1649809440000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1417878112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,22]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1,6]]}},"alternative-id":["10.1073\/pnas.1417878112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1417878112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,22]]},"assertion":[{"value":"2014-12-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}