{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:38:57Z","timestamp":1791329937894,"version":"4.3.1"},"reference-count":30,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC000210 and DC012441"],"award-info":[{"award-number":["DC000210 and DC012441"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC010894"],"award-info":[{"award-number":["DC010894"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC012130"],"award-info":[{"award-number":["DC012130"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"HHS | NIH | National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["DC011134"],"award-info":[{"award-number":["DC011134"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,5,5]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The constant generation of olfactory sensory neurons throughout life makes the system appealing for studies of the mechanisms of axon extension and connectivity. Understanding the mechanisms leading to the genesis of these new neurons is fundamental for the development of therapeutic treatments. We provide here, to our knowledge, the first detailed analysis of the sequential steps leading toward fully differentiated sensory neurons. We show that odorant receptors are not involved in the initial steps of differentiation, but only later in the final process of maturation. Moreover, the proteins that we studied here also have been implicated in normal and pathophysiological events ranging from kidney function to cancer development, making our data valuable across different disciplines.<\/jats:p>","DOI":"10.1073\/pnas.1417955112","type":"journal-article","created":{"date-parts":[[2015,4,20]],"date-time":"2015-04-20T22:51:43Z","timestamp":1429570303000},"page":"5821-5826","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":83,"title":["Odorant receptors regulate the final glomerular coalescence of olfactory sensory neuron axons"],"prefix":"10.1073","volume":"112","author":[{"given":"Diego J.","family":"Rodriguez-Gil","sequence":"first","affiliation":[{"name":"Departments of aNeurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianna L.","family":"Bartel","sequence":"additional","affiliation":[{"name":"Departments of aNeurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Austin W.","family":"Jaspers","sequence":"additional","affiliation":[{"name":"Departments of aNeurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arie S.","family":"Mobley","sequence":"additional","affiliation":[{"name":"Departments of aNeurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumiaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Departments of aNeurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles A.","family":"Greer","sequence":"additional","affiliation":[{"name":"Departments of aNeurosurgery,"},{"name":"Neurobiology, and"},{"name":"The Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT 06520-8082"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,4,20]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007931107"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81387-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.013"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.05.011"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0813224106"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ar.10047"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2005.03.027"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-007-9141-2"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018472"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10182"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-07-02469.2002"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2010.07458.x"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2013.05.002"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.06.039"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609215104"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1131794"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4225-10.2010"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.08.033"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001568"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.046"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.10.050"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1502-10.2010"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248805"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1248806"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019694"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5566-07.2008"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2943"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(80)90062-7"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21834"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0610155104"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1417955112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1417955112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:43:31Z","timestamp":1649810611000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1417955112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4,20]]},"references-count":30,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2015,5,5]]}},"alternative-id":["10.1073\/pnas.1417955112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1417955112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4,20]]},"assertion":[{"value":"2015-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}