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Analyses of A-T patients revealed elevated levels of NOX4 in the cerebellum that also correlated with increased levels of DNA damage and apoptosis. These observations were substantiated by the absence of abnormal NOX4 cerebellar expression in mouse models of A-T disease which do not display cerebellar degeneration. However, injecting A-T mice with NOX4 inhibitor decreased their elevated cancer incidence. Therefore, NOX4 appears as a critical mediator in A-T disease.<\/jats:p>","DOI":"10.1073\/pnas.1418139112","type":"journal-article","created":{"date-parts":[[2015,2,2]],"date-time":"2015-02-02T23:18:45Z","timestamp":1422919125000},"page":"2121-2126","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["NADPH oxidase 4 is a critical mediator in Ataxia telangiectasia disease"],"prefix":"10.1073","volume":"112","author":[{"given":"Urbain","family":"Weyemi","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe E.","family":"Redon","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Towqir","family":"Aziz","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rohini","family":"Choudhuri","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Maeda","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Palak R.","family":"Parekh","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael Y.","family":"Bonner","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Atlanta Veterans Administration Medical Center, Emory University, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack L.","family":"Arbiser","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Atlanta Veterans Administration Medical Center, Emory University, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"Bonner","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Pharmacology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,2,2]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"285","article-title":"The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress","volume":"29","author":"Rotman G","year":"1997","unstructured":"G Rotman, Y Shiloh, The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls and cellular defence against oxidative stress. 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