{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:53:44Z","timestamp":1793048024281,"version":"4.5.0"},"reference-count":25,"publisher":"National Academy of Sciences","issue":"10","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,3,10]]},"abstract":"Significance<\/jats:title>\n \n Several\n Plasmodium<\/jats:italic>\n species exhibit age-based preference for the red blood cells (RBC) they invade, with implications for virulence and disease severity. CD47, a marker of self, prevents the early clearance of cells by phagocytosis. We report here that in the absence of CD47, growth of a\n Plasmodium<\/jats:italic>\n species that preferentially infects CD47\n hi<\/jats:sup>\n young RBC is highly attenuated, and the macrophages from CD47\n \u2212\/\u2212<\/jats:sup>\n mice are more effective in phagocytizing the malaria-parasitized RBC than wild-type mice. We suggest that preferential invasion of young RBC is an evolutionary adaptation that shields the malaria parasite from phagocytic clearance and controls parasitemia, as fewer RBC are available for invasion. Modulation of CD47 levels by antibody treatment may have therapeutic value in patients with severe malaria.\n <\/jats:p>","DOI":"10.1073\/pnas.1418144112","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T17:27:01Z","timestamp":1424885221000},"page":"3062-3067","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":51,"title":["CD47 regulates the phagocytic clearance and replication of the\n Plasmodium yoelii<\/i>\n malaria parasite"],"prefix":"10.1073","volume":"112","author":[{"given":"Rajdeep","family":"Banerjee","sequence":"first","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Khandelwal","sequence":"additional","affiliation":[{"name":"Department of Medicine, Duke University Medical Center, Durham, NC 27710"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Kozakai","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bikash","family":"Sahu","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjai","family":"Kumar","sequence":"additional","affiliation":[{"name":"Laboratory of Emerging Pathogens, Division of Emerging and Transfusion Transmitted Diseases, Office of Blood Research and Review, Center for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD 20993; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,2,23]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0308256101"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.8.2677"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00027-13"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.2307\/3285103"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1645\/0022-3395(2002)088[0521:PVBSD]2.0.CO;2"},{"key":"e_1_3_3_6_2","first-page":"12","volume-title":"Essential malariology","author":"Gilles HM","year":"1993","unstructured":"HM Gilles, The malaria parasites. 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