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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,14]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Excess androgens and abnormal follicle development, largely due to ovarian granulosa cell (GC) dysfunction, characterize polycystic ovary syndrome (PCOS), a common endocrinopathy of women predisposing to infertility. Thus, it is important to understand GC dysfunction. The androgen receptor (AR) is widely believed to be an essential regulator of GC biology. High expression of AR in GCs is primarily considered to associate with PCOS. However, we show that AR alternative splice variants in GCs disturb androgen metabolism and follicle growth, leading to PCOS because of impaired transcription factor function. These data considerably change our understanding of the role of AR in the etiology of PCOS, and inform the development of clinical diagnostic and classification tests as well as novel therapeutic interventions.<\/jats:p>","DOI":"10.1073\/pnas.1418216112","type":"journal-article","created":{"date-parts":[[2015,4,1]],"date-time":"2015-04-01T05:46:36Z","timestamp":1427867196000},"page":"4743-4748","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":104,"title":["Alternative splicing of the androgen receptor in polycystic ovary syndrome"],"prefix":"10.1073","volume":"112","author":[{"given":"Fangfang","family":"Wang","sequence":"first","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexue","family":"Pan","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Liu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Meng","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Lv","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Qu","sequence":"additional","affiliation":[{"name":"The Key Laboratory of Reproductive Genetics, Ministry of Education (Zhejiang University), Hangzhou 310058, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Lian","family":"Ding","sequence":"additional","affiliation":[{"name":"The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Klausen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Child and Family Research Institute, University of British Columbia, Vancouver, BC, Canada V5Z 4H4;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C. 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