{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T15:59:37Z","timestamp":1781107177150,"version":"3.54.1"},"reference-count":40,"publisher":"National Academy of Sciences","issue":"16","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"name":"HHS | National Institutes of Health","award":["EY012135"],"award-info":[{"award-number":["EY012135"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Humans and animals often choose between targets in space. Parietal cortex is known to be critical to this function. However, the exact role of parietal cortex in spatial choice remains controversial. Does parietal cortex implement choices at the general cognitive level, or are the choices made in the context of specific upcoming actions? We placed focused reversible lesions into specific parietal circuits of monkeys making choices between two targets. Lesions of specific circuits only affected choices made using specific actions: lesions of lateral intraparietal area (LIP) affected eye movements but not reaches, while lesions of the parietal reach region had converse effects. This illuminates the nature of spatial choice in parietal cortex, and suggests that choice is implemented in dedicated parietal circuits, each responsible for a specific class of actions.<\/jats:p>","DOI":"10.1073\/pnas.1418324112","type":"journal-article","created":{"date-parts":[[2015,3,10]],"date-time":"2015-03-10T22:52:55Z","timestamp":1426027975000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":35,"title":["Motor role of parietal cortex in a monkey model of hemispatial neglect"],"prefix":"10.1073","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0527-5559","authenticated-orcid":false,"given":"Jan","family":"Kubanek","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110; and"},{"name":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6519-3462","authenticated-orcid":false,"given":"Jingfeng M.","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3776-0199","authenticated-orcid":false,"given":"Lawrence H.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, MO 63110; and"},{"name":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO 63130"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,3,10]]},"reference":[{"key":"e_1_3_3_1_2","first-page":"529","article-title":"\u00dcber eine durch eine klinisch bisher nicht verwerthete Untersuchungsmethode ermittelte Form der Sensibilit\u00e4tsst\u00f6rung bei einseitigen Erkrankugen des Gro\u00dfhirns","volume":"4","author":"Oppenheim H","year":"1885","unstructured":"H Oppenheim, \u00dcber eine durch eine klinisch bisher nicht verwerthete Untersuchungsmethode ermittelte Form der Sensibilit\u00e4tsst\u00f6rung bei einseitigen Erkrankugen des Gro\u00dfhirns. Neurologisches Centralblatt 4, 529\u2013533 (1885).","journal-title":"Neurologisches Centralblatt"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410050210"},{"key":"e_1_3_3_3_2","first-page":"67","volume-title":"Handbook of Neuropsychology: Disorders of Visual Behavior","author":"Bartolomeo P","year":"2000","unstructured":"P Bartolomeo, S Chokronc, Levels of impairment in unilateral neglect. Handbook of Neuropsychology: Disorders of Visual Behavior, eds F Boller, J Grafman (Gulf Professional Publishing, Amsterdam) Vol 4, 67 (2000)."},{"key":"e_1_3_3_4_2","first-page":"279","article-title":"Neglect and related disorders","volume":"3","author":"Heilman KM","year":"1993","unstructured":"KM Heilman, RT Watson, E Valenstein, Neglect and related disorders. Clinical Neuropsychology 3, 279\u2013336 (1993).","journal-title":"Clinical Neuropsychology"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410100402"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(96)00093-0"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(94)00111-2"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.22-22-09877.2002"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/13506289408402295"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410030609"},{"key":"e_1_3_3_11_2","first-page":"263","volume-title":"Analysis of Visual Behavior","author":"Goodale MA","year":"1982","unstructured":"MA Goodale, DJ Ingle, RJ Mansfield Analysis of Visual Behavior (MIT Press, Cambridge, MA), pp. 263\u2013299 (1982)."},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.4.1943"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/acprof:oso\/9780198524724.001.0001"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn0901-953"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1162\/089892901753165836"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/32413"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0243-09.2009"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3932(03)00038-1"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2004.03.012"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/693"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2496"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.10.030"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-02-00632.2003"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2004.04.003"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.7551\/mitpress\/9780262195805.003.0004"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.003"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.08.028"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1220508110"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380508"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/115.5.1387"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.3.1473"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.8.1278"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2221"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(04)00185-0"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0482"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.10.011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-3702(03)00054-7"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature04676"},{"key":"e_1_3_3_39_2","unstructured":"Committee on Care and Use of Laboratory Animals (1996) Guide for the Care and Use of Laboratory Animals (Natl Inst Health Bethesda) DHHS Publ No (NIH) 85-23."},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00883.2002"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1418324112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1418324112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:18:01Z","timestamp":1649809081000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1418324112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,10]]},"references-count":40,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2015,4,21]]}},"alternative-id":["10.1073\/pnas.1418324112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1418324112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,10]]},"assertion":[{"value":"2015-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}