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We have recently shown that selective blockade of peripheral cannabinoid receptor-1 (CB\n                    <jats:sub>1<\/jats:sub>\n                    R) delayed and attenuated the development of type 2 diabetes in a rat model. Here we show that the nephropathy-inducing effects of both hyperglycemia and activation of the RAS involve CB\n                    <jats:sub>1<\/jats:sub>\n                    R activation in glomerular podocytes, and that antagonism of peripheral CB\n                    <jats:sub>1<\/jats:sub>\n                    R could represent a novel, effective, and rational approach to both prevent and reverse diabetic nephropathy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1419901111","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T23:48:51Z","timestamp":1416872931000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":133,"title":["Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy"],"prefix":"10.1073","volume":"111","author":[{"given":"Tony","family":"Jourdan","sequence":"first","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerg\u0151","family":"Szanda","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avi Z.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Kidney Diseases Section, National Institute on Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"},{"name":"The Johns Hopkins University School of Medicine, Baltimore, MD 21205; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Tam","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian James","family":"Earley","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Godlewski","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Resat","family":"Cinar","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Ju","sequence":"additional","affiliation":[{"name":"Skaggs School of Pharmacy and Pharmaceutical Sciences, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Pacher","sequence":"additional","affiliation":[{"name":"Section on Oxidative Stress and Tissue Injury, Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Kunos","sequence":"additional","affiliation":[{"name":"Laboratory of Physiologic Studies, Section on Neuroendocrinology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2014,11,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-007-0076-5"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.07715.x"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20130065"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00086.x"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.11.003"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12260"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-24716-3_17"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1336"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1423"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002540"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1463-1326.2012.01563.x"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1506-7"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42551"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.002"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3265"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780392"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00836.x"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.fjc.0000245241.79959.d6"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1124\/pr.58.1.6"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/oby.20061"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1089\/met.2008.0045"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00758.2002"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013080859"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.2174\/1573399052952622"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2012.07.020"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.527"},{"key":"e_1_3_3_27_2","first-page":"1133","article-title":"Expression of cannabinoid receptors in human kidney","volume":"25","author":"Larrinaga G","year":"2010","unstructured":"G Larrinaga, , Expression of cannabinoid receptors in human kidney. 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