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Although both ST3Gal-IV and ST6Gal-I sialyltransferases mask galactose linkages implicated as asialoglycoprotein receptor ligands, only ST3Gal-IV deficiency promotes asialoglycoprotein clearance mechanisms with a reduction in plasma levels of VWF and platelets. Exposed galactose on VWF was also found in a subpopulation of humans with abnormally low VWF levels. Oligosaccharide branch-specific sialylation by the ST3Gal-IV sialyltransferase is required to sustain the physiologic half-life of murine hemostatic components and may be an important modifier of plasma VWF level in humans.<\/jats:p>","DOI":"10.1073\/pnas.142005099","type":"journal-article","created":{"date-parts":[[2002,7,28]],"date-time":"2002-07-28T18:26:28Z","timestamp":1027880788000},"page":"10042-10047","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":177,"title":["Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands"],"prefix":"10.1073","volume":"99","author":[{"given":"Lesley G.","family":"Ellies","sequence":"first","affiliation":[{"name":"Howard Hughes Medical Institute, Glycobiology Research and Training Center, and Departments of Cellular and Molecular Medicine, Medicine, and Pathology, 9500 Gilman Drive 0625, University of California San Diego, La Jolla, CA 92093; 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