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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,21]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The airway pathogen\n                    <jats:italic>Mycoplasma pneumoniae<\/jats:italic>\n                    (\n                    <jats:italic>Mp<\/jats:italic>\n                    ) produces a virulence factor with ADP-ribosyltransferase and vacuolating activities known as Community-Acquired Respiratory Distress Syndrome Toxin (CARDS TX). Mammalian cells exposed to recombinant CARDS TX exhibit distinct patterns of ADP-ribosylated proteins and unusual vacuolation phenotypes with disruption of monolayer integrity, leading to cell death. Recombinant CARDS TX administered to naive mice induces an allergic-type inflammatory response and airway hyperreactivity, suggesting that an analogous response in humans may play a causal role in\n                    <jats:italic>Mp<\/jats:italic>\n                    -associated asthma. Here we present the structure of CARDS TX, the newest member of the well-recognized group of ADP-ribosylating toxins. The structure enhances understanding of\n                    <jats:italic>Mp<\/jats:italic>\n                    pathogenicity and provides a platform for the development of therapies to treat\n                    <jats:italic>Mp<\/jats:italic>\n                    -associated acute and chronic airway diseases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1420308112","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T22:23:05Z","timestamp":1428358985000},"page":"5165-5170","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":83,"title":["Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from\n                    <i>Mycoplasma pneumoniae<\/i>"],"prefix":"10.1073","volume":"112","author":[{"given":"Argentina","family":"Becker","sequence":"first","affiliation":[{"name":"Department of Biochemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. R.","family":"Kannan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology\/Center for Airway Inflammation Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander B.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"X-Ray Crystallography Core Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4950-4130","authenticated-orcid":false,"given":"Olga N.","family":"Pakhomova","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Frank Reidy Center for Bioelectrics, Old Dominion University, Norfolk, VA 23508;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha R.","family":"Somarajan","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology\/Center for Airway Inflammation Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Galaleldeen","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"Department of Biological Sciences, St. Mary's University, San Antonio, TX 78228; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen P.","family":"Holloway","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel B.","family":"Baseman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology\/Center for Airway Inflammation Research, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. John","family":"Hart","sequence":"additional","affiliation":[{"name":"Department of Biochemistry,"},{"name":"X-Ray Crystallography Core Laboratory, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229;"},{"name":"South Texas Veterans Health Care System, US Department of Veterans Affairs, San Antonio, TX 78229"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_3_4_1_2","unstructured":"; Centers for Disease Control and Prevention National Center for Immunization and Respiratory Diseases Mycoplasma pneumoniae infection: Surveillance and reporting. Available at www.cdc.gov\/pneumonia\/atypical\/mycoplasma\/surv-reporting.html. Accessed March 15 2015. 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