{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:04:53Z","timestamp":1789560293863,"version":"build-2803163510"},"reference-count":24,"publisher":"National Academy of Sciences","issue":"14","license":[{"start":{"date-parts":[[2015,3,24]],"date-time":"2015-03-24T00:00:00Z","timestamp":1427155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL094520"],"award-info":[{"award-number":["R01-HL094520"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01-HL102969"],"award-info":[{"award-number":["R01-HL102969"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Smooth muscle cells (SMCs) play critical roles in maintaining organismal homeostasis. Myocardin is a muscle-restricted transcriptional coactivator previously implicated in development of the heart and vasculature. To define myocardin-mediated functions during postnatal development, we generated mice harboring an inducible, SMC-restricted mutation in the\n                    <jats:italic>Myocd<\/jats:italic>\n                    gene. Myocardin mutant mice exhibit profound derangements in arterial structure and in the gastrointestinal and genitourinary tracts.\n                    <jats:italic>Myocd<\/jats:italic>\n                    deletion leads to the loss of the contractile SMC phenotype, triggering cell-autonomous ER stress, autophagy, and apoptosis. These data reveal that myocardin is required for maintenance, homeostasis, and ultimately survival of vascular and visceral SMCs during postnatal development. These findings provide unanticipated insights into the pathogenesis of thoracic aortic aneurysm and dissection and gastrointestinal and genitourinary syndromes.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1420363112","type":"journal-article","created":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T01:41:08Z","timestamp":1427247668000},"page":"4447-4452","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":95,"title":["Myocardin is required for maintenance of vascular and visceral smooth muscle homeostasis during postnatal development"],"prefix":"10.1073","volume":"112","author":[{"given":"Jianhe","family":"Huang","sequence":"first","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander C.","family":"Wright","sequence":"additional","affiliation":[{"name":"Radiology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifu","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Zhou","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisheng","family":"Yang","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aeron","family":"Small","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael S.","family":"Parmacek","sequence":"additional","affiliation":[{"name":"Cardiovascular Institute and Departments of"},{"name":"Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,3,24]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00041.2003"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000259563.61091.e8"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1428006"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.222561499"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63635"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0910749106"},{"key":"e_1_3_3_7_2","first-page":"515","article-title":"Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice","volume":"118","author":"Huang J","year":"2008","unstructured":"J Huang, , Myocardin regulates expression of contractile genes in smooth muscle cells and is required for closure of the ductus arteriosus in mice. 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