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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,8,4]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\u03b3\u03b4 T cells producing IL-17 (\u03b3\u03b4-17 cells) play an important role in promoting inflammation, but the mechanisms that regulate their development are still being explored. IL-15 and its receptor, IL-15R\u03b1, function largely to promote the development and survival of lymphoid cells. Here we show that IL-15R\u03b1 signaling has an opposing effect on the \u03b3\u03b4-17 population, such that a deficiency in IL-15R\u03b1 increases \u03b3\u03b4-17 cells and their precursors. This work establishes a direct role for IL-15R\u03b1 signaling in vivo and raises questions about the role of IL-15 itself in this process.<\/jats:p>","DOI":"10.1073\/pnas.1420741112","type":"journal-article","created":{"date-parts":[[2015,7,20]],"date-time":"2015-07-20T20:23:40Z","timestamp":1437423820000},"page":"9692-9697","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":28,"title":["IL-15 receptor \u03b1 signaling constrains the development of IL-17\u2013producing \u03b3\u03b4 T cells"],"prefix":"10.1073","volume":"112","author":[{"given":"Sara L.","family":"Colpitts","sequence":"first","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and Vaccine Research, UConn Health, Farmington, CT 06030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Puddington","sequence":"additional","affiliation":[{"name":"Department of Immunology, Center for Integrated Immunology and 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