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Here we report that the pathway leading to calpain activation offers potential drug targets for Wolfram syndrome and substrates for calpain might serve as biomarkers for this syndrome.<\/jats:p>","DOI":"10.1073\/pnas.1421055111","type":"journal-article","created":{"date-parts":[[2014,11,24]],"date-time":"2014-11-24T23:48:51Z","timestamp":1416872931000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":147,"title":["A calcium-dependent protease as a potential therapeutic target for Wolfram syndrome"],"prefix":"10.1073","volume":"111","author":[{"given":"Simin","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, St. Louis, MO 63110;"},{"name":"Graduate School of Biomedical Sciences, University of Massachusetts Medical School, Worcester, MA 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