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U.S.A."],"published-print":{"date-parts":[[2015,4,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The rhinovirus C (RV-C) species was first identified in 2006 and is a major cause of acute respiratory illnesses in children and hospitalizations for exacerbations of asthma. In this study, we discovered that expression of human cadherin-related family member 3 (CDHR3), a transmembrane protein with yet unknown biological function, enables RV-C binding and replication in normally unsusceptible host cells. Intriguingly, we found that a coding SNP (rs6967330, C\n                    <jats:sub>529<\/jats:sub>\n                    Y) in CDHR3, previously linked to wheezing illnesses and hospitalizations for childhood asthma by genetic analysis, also mediates enhanced RV-C binding and increased progeny yields in vitro. Finally, using structural modeling, we identified potential binding sites in CDHR3 domains 1 and 2 interacting with viral capsid surface regions that are highly conserved among RV-C types.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1421178112","type":"journal-article","created":{"date-parts":[[2015,4,6]],"date-time":"2015-04-06T22:23:05Z","timestamp":1428358985000},"page":"5485-5490","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":412,"title":["Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication"],"prefix":"10.1073","volume":"112","author":[{"given":"Yury A.","family":"Bochkov","sequence":"first","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Watters","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shamaila","family":"Ashraf","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodor F.","family":"Griggs","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Devries","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel J.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C.","family":"Palmenberg","sequence":"additional","affiliation":[{"name":"Institute for Molecular Virology, University of Wisconsin\u2013Madison, Madison, WI 53706"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Gern","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and"},{"name":"Department of Medicine, University of Wisconsin\u2013Madison, Madison, WI 53792; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,4,6]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1086\/508551","article-title":"MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005","volume":"194","author":"Lamson D","year":"2006","unstructured":"D Lamson, , MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005. 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