{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:20:09Z","timestamp":1792110009746,"version":"4.4.0"},"reference-count":50,"publisher":"National Academy of Sciences","issue":"14","license":[{"start":{"date-parts":[[2015,9,23]],"date-time":"2015-09-23T00:00:00Z","timestamp":1442966400000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"name":"National Institute of Health","award":["CA151248"],"award-info":[{"award-number":["CA151248"]}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2015,4,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Cancer stem cells (CSCs) exhibit enhanced chemo\/radiotherapy resistance, and their survival following cancer treatment is believed to be responsible for tumor recurrence and metastasis. Thus, understanding the mechanisms through which CSCs survive conventional chemotherapy is essential for identification of new therapeutic strategies to prevent tumor relapse. Our findings that ovarian CSCs survive cisplatin treatment through elevated expression of polymerase \u03b7 represent an opportunity to eradicate CSCs and improve the survival of ovarian cancer patients. In addition, identification of miR-93 as the regulator of polymerase \u03b7 expression provides a target to increase the efficacy of cisplatin treatment.<\/jats:p>","DOI":"10.1073\/pnas.1421365112","type":"journal-article","created":{"date-parts":[[2015,3,23]],"date-time":"2015-03-23T23:17:43Z","timestamp":1427152663000},"page":"4411-4416","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":179,"title":["Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells"],"prefix":"10.1073","volume":"112","author":[{"given":"Amit Kumar","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhua","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ran","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Radiology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuntao","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Molecular Virology, Immunology and Medical Genetics,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlene","family":"Mao","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiqiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pathology,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Yu","sequence":"additional","affiliation":[{"name":"Comprehensive Cancer Center,"},{"name":"Division of Hematology\/Oncology, The Ohio State University, Columbus, OH 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-En","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology,"},{"name":"Comprehensive Cancer Center,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2015,3,23]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21208"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2006.03.012"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1123"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6603(01)67026-0"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1021\/cr068207j"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(98)90056-1"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2004.08.008"},{"key":"e_1_3_3_8_2","first-page":"3500","article-title":"Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines","volume":"54","author":"Mamenta EL","year":"1994","unstructured":"EL Mamenta, , Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res 54, 3500\u20133505 (1994).","journal-title":"Cancer Res"},{"key":"e_1_3_3_9_2","first-page":"3968","article-title":"Efficient nucleotide excision repair of cisplatin, oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts","volume":"59","author":"Reardon JT","year":"1999","unstructured":"JT Reardon, A Vaisman, SG Chaney, A Sancar, Efficient nucleotide excision repair of cisplatin, oxaliplatin, and Bis-aceto-ammine-dichloro-cyclohexylamine-platinum(IV) (JM216) platinum intrastrand DNA diadducts. Cancer Res 59, 3968\u20133971 (1999).","journal-title":"Cancer Res"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-1328"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.281"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1202681109"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-05-0118"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011412107"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.076828"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.020446"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011409107"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.8.1.7533"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0364"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1206400109"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3175"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.58.062105.204854"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3126"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/941876"},{"key":"e_1_3_3_25_2","first-page":"68","article-title":"cis-Diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells","volume":"48","author":"Andrews PA","year":"1988","unstructured":"PA Andrews, S Velury, SC Mann, SB Howell, cis-Diamminedichloroplatinum(II) accumulation in sensitive and resistant human ovarian carcinoma cells. Cancer Res 48, 68\u201373 (1988).","journal-title":"Cancer Res"},{"key":"e_1_3_3_26_2","first-page":"245","article-title":"DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines","volume":"39","author":"Delmastro DA","year":"1997","unstructured":"DA Delmastro, J Li, A Vaisman, M Solle, SG Chaney, DNA damage inducible-gene expression following platinum treatment in human ovarian carcinoma cell lines. Cancer Chemother Pharmacol 39, 245\u2013253 (1997).","journal-title":"Cancer Chemother Pharmacol"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-13-0638"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.12-218222"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(01)00141-5"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-08-1227"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-8-126"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083978"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1186\/1476-4598-12-24"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905653106"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-1035"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2004.08.011"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1021\/bi000130k"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/19.12.3100"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1768"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1616307"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002751"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.465"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.022"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2004.06.023"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2006.11.001"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.23145"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3557"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040021"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1042\/BST0360114"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3184"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1421365112","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1421365112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:34:24Z","timestamp":1649810064000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1421365112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,23]]},"references-count":50,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2015,4,7]]}},"alternative-id":["10.1073\/pnas.1421365112"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1421365112","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,23]]},"assertion":[{"value":"2015-03-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}